Protective Effects of Tephrosialu Pinifolia Dc. Against Cadmium Induced Renal Toxicity in Sprague Dawley Rats | [First International Conference on Revamped Scientific Outlook of 21st Century (Abstract Book) • 2022]

Author(s):

1. Umbreen Rashid: Department of Life Sciences, Abasyn University, Islamabad Campus, Pakistan;Department of Zoology, Government College Women University, Lahore, Pakistan

2. Zunaira Rahat: Department of Zoology, Government College Women University,Lahore,Pakistan

3. Iqra Aslam: Department of Microbiology, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan

4. Jannat: Department of Zoology, Government College Women University,Lahore,Pakistan

5. Sajida Mushtaq: Department of Zoology, Government College Women University,Lahore,Pakistan

Abstract:

Cadmium is a common environmental pollutant which is linked with a variety of adverse health effects such as renal impairment, carcinogenesis, hepatotoxicity as well as disruption of normal endocrine and reproductive functions. Tephrosialu Pinifolia Dc belongs to the family “Fabaceae” and is traditionally used in the treatment of urinary disorders, stomach ache, diarrhea, rheumatism and asthma. Effects of Tephrosialu Pinifolia Dc pre-treatment were investigated in cadmium induced changes on renal function tests including creatinine, urea, uric acid and blood urea nitrogen. In this study, male rats were administrated (orally) with TLM (25, 50 mg/kg) for seven days and then injected (intravenously) with cadmium (CdCl2, 4 mg/kg) to induce acute renal toxicity. Creatinine, urea and blood urea nitrogen levels were decreased while uric acid increases due to cadmium administration when compared to control rats. Treatment of Tephrosialu Pinifolia Dc. to rats improved cadmium induced toxicity and restored these values towards normal. The present study suggested the preventive potentials of Tephrosialu Pinifolia Dc against the cadmium induced renal toxicity that justifies its uses for the cure of various diseases particularly urinary and gastrointestinal disorders.

Page(s): 0-0

DOI: DOI not available

Published: Journal: First International Conference on Revamped Scientific Outlook of 21st Century (Abstract Book), Volume: 0, Issue: 0, Year: 2022

Keywords:

Cadmium , Renal toxicity , Tephrosia lupinifolia

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