Abstract:
Objective: This research is aimed to explore the relationship between vitamin D and lipid pro le in females with PCOS and non-PCOS infertile female subjects. Study Design: Comparative descriptive study. Place and Duration of the Study: Department of Biological and Biomedical Sciences, The Aga Khan University, Karachi, Pakistan and Jinnah Postgraduate Medical Centre, Karachi, Pakistan in collaboration with the Australian Concept Infertility Medical Centre, from February 2021 to March 2023. Methodology: A total of 180 infertile women with 120 PCOS and 60 non-PCOS were enrolled. The lipid pro le and BMI of the patients were acquired from desk records, and vitamin D was estimated by enzyme-linked immunosorbent assay (ELISA). Participants were classi ed according to their vitamin D levels as su cient (30-100 ng/ml), insu cient (20-29 ng/ml), or de cient (below 20 ng/ml). Median, interquartile range, frequency, and percentages were described. Statistical signi cance was calculated by Mann-Whitney U and Chi-square tests with p-values of 0.05. Results: Females with PCOS had signi cantly low vitamin D (p <0.001). Total cholesterolol,w-density lipoprotein, very low-density lipoprotein, and triglyceride levels were signi cantly increased, and high-density lipoprotein cholesterol (HDL) was less in comparison to the non-PCOS group (p <0.001). A signi cant increase in total cholesterol, triglycerides, low-density lipoproteins, and very low-density lipoproteins was found in the vitamin D de cient subgroup compared with insu cient or su cient groups (p = 0.05). Conclusion: The study provides a link between females with PCOS and abnormalities in lipid pro le. Decreased vitamin D levels in females with PCOS were linked with an abnormal lipid pro le characterised by rise in cholesterol, triglycerides, and low-density lipoproteins which may lead to metabolic abnormalities.
Keywords:
Body mass index
,
Metabolic syndrome
,
Vitamin D
,
Polycystic ovary syndrome
,
Lipid pro le