Author(s):
1. Syed Shahab Ud Din Shah:
Department of Biochemistry, Quaid-i-Azam University Islamabad,Pakistan
2. Shah Hussain:
Department of Biochemistry, Quaid-i-Azam University Islamabad,Pakistan
Abstract:
Alzheimer's disease (AD) is a common form of dementia, affecting millions of people worldwide, mostly the elderly population. The gradual decline in cognitive functions, loss of memory, and sleep disorder are the most frequently reported in AD patients. Multiple studies have been carried out to find a potential therapeutic approach to prevent the progression of Alzheimer's disease and increase the performance of cognitive abilities. Mitochondrial dysfunction leading to oxidative stress and other environmental factors, diet and lifestyle are the major risk factors. Mitochondria play an essential role and are a potential therapeutic target for treating and preventing AD progression. Various biochemical molecules involved in mitochondrial metabolic pathways are tested as directly acting on mitochondria. Numerous antioxidants are considered as a potential treatment for AD. Here, we highlighted the emerging mitochondrial base therapies and potent antioxidants that can be used in Alzheimer's disease treatments.
Page(s):
175-183
Published:
Journal: Abasyn Journal of Life Sciences, Volume: 3, Issue: 2, Year: 2020
Keywords:
antioxidants
,
Alzheimers Disease
,
mitochondria
,
therapies
References:
References are not available for this document.
Citations
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