The homeostasis boosting effects of Curcuma longa in nitro-methane sulfonamide induced hepatic stress in male albino wistar rats. | [Isra Medical Journal • 2014]

Author(s):

1. Abroo Fatima Qazi: Department of Physiology, Isra University, Hyderabad, Pakistan

2. Din Muhammad Shaikh: Department of Physiology, Isra University, Hyderabad, Pakistan

3. Saif-Ur-Rehman: Department of Physiology, Isra University, Hyderabad, Pakistan

4. Hamid Zia Shaikh: Department of Physiology, Isra University, Hyderabad, Pakistan

Abstract:

OBJECTIVE: To observe the protective effect of Curcuma Longa in Nitro-Methane Sulfonamide induced hepatotoxicity. STUDY DESIGN: Experimental Case Control Study PLACE AND DURATION: Departments of Physiology and Postgraduate Research Lab of ISRA University Hyderabad, from 1st June 2012 to 31st December 2012. METHODOLOGY: 40 male albino Wistar rats were equally divided into four groups of 10 each. Group A used as the control group and was fed the normal rat chow for 09 days. Group B was fed with Nitro-Methane sulfonamide for 09 days followed by Curcuma Longa for next 09 days. Group C was given Curcuma Longa for 09 days followed by Nitro-Methanesulfonamide for next 09 days. Group D was given Nitro-Methane sulfonamide in combination with Curcuma Longa for 09 days. After 24 hours of feeding, blood samples from groups A and D were taken from dorsal vein in the tail of rats for biochemical analysis of serum levels of ALT, AST, ALP and ã-GT at days 01 and 09 & for groups B and C blood samples were collected at day 01, day 09 and day 18. RESULTS: The analysis showed that prevention from the Nitro-Methane sulfonamide induced hepatotoxicity by the Curcuma Longa administration was observed after 18 days with a p value

Page(s): 146-150

DOI: DOI not available

Published: Journal: Isra Medical Journal, Volume: 6, Issue: 3, Year: 2014

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