Use of anti-interleukin 6 receptor monoclonal antibody for the treatment of Endometriosis | [Bioscience Research • 2022]

Author(s):

1. Amoura M. Abou-EL-Naga: Department of Zoology, Faculty of science, Mansoura University,Mansoura,Egypt

2. Ahmed A. El-Zayadi: Department of Obstetrics& Gynecology, Faculty of Medicine, Mansoura University Mansoura,,Egypt

3. Yasmin M. Tag: Department of Oral Biology, Faculty of oral & Dental Medicine, Delta Unversity for Science & Technology,Gamasa,Egypt

4. Nada M. Fawzy: Department of Zoology, Faculty of science, Mansoura University,Mansoura,Egypt

Abstract:

IL-6 dysregulation is implicated in numerous clinical symptoms of endometriosis. Recent anti-IL-6 and anti-TNF therapies have resulted in clinical improvements in endometriosis patients' signs and symptoms as well as their quality of life. This study has shown the efficacy of tocilizumab drug as an anti-IL-6 receptor monoclonal antibody for endometriosis therapy in an experimental rat model. Il-6 expression is consistent with endometriosis in humans. As a result, this model might be useful in researching the pathogenesis and therapy of endometriosis. 18 female Sprague Dawley rats were employed as an experimental model for endometriosis. Following the induction surgery of endometriosis, the surviving rats were separated into two groups: the treatment group, which obtained tocilizumab, and the control group, which received saline. The volumes and histopathological properties of the implants were evaluated before and after the induction surgery and the usage of the TCZ medication. IL6 expression was evaluated via qRT-PCR in all lesions. Immunohistochemistry was also used to detect tumor necrosis factor alpha (TNF-a) intensity in ectopic& eutopic endometrium. There was a significant difference in post-treatment spherical volume between the TCZ and control groups. Implant volumes of TCZ group were lower than those of the control group respectively (70.74± 51.15 VS 113.58± 50.69; P= 0.04b). Comparing eutopic with ectopic lesions, we demonstrated that IL-6 gene expression inside the control group was higher than in the TCZ group. According to histopathological evaluation, the epithelium of eutopic endometrium in both groups was observed to be more preserved than the ectopic implant. Interleukin 6 blockers, which have been utilized to treat related auto-immune disorders, might open up a recent avenue for the use of an immunemodulatory biologic medication for endometriosis therapy.

Page(s): 836-843

DOI: DOI not available

Published: Journal: Bioscience Research, Volume: 19, Issue: 2, Year: 2022

Keywords:

Infertility Endometriosis Interleukin6Tumor Necrosis Factora

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