Acute Stress Induced Behavioral Deficits In Rats: Relationship With Oxidative Stress, Leptin And HPA Axis. | [Journal of Chemical Society of Pakistan • 2019]

Author(s):

1. Erum Shireen: Neurochemistry and Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, Pakistan

2. Wafa Binte Ali: Neurochemistry and Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, Pakistan

3. Maria Masroor: Neurochemistry and Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, Pakistan

4. Saeeda Bano: Senior Scientific Officer, PCSIR Labs. Complex, Karachi. Shahrah-e-Salimuzzman Siddiqui, University road, Karachi, Pakistan

5. Samina Iqbal: Senior Scientific Officer, PCSIR Labs. Complex, Karachi. Shahrah-e-Salimuzzman Siddiqui, University road, Karachi, Pakistan

6. Muhammad Mansoor Hai: In-charge MIS, PCSIR Labs. Complex, Karachi. Shahrah-e-Salimuzzman Siddiqui, University road, Karachi, Pakistan

7. Darakhshan J Haleem: Neuroscience Research Laboratory, Dr. Panjwani Center for Molecular Medicine & Drug Research, University of Karachi, Karachi, Pakistan

Abstract:

Summary: Acute exposure to stress is connected to many disorders that promote the toxicity of oxygen radical generators leading to increase in the levels of enzymes and also the activation of the HPA axis. The present study uses a preclinical approach to elucidate some prospective stressinduced behavioral and biochemical effects. The aim of current study was to investigate the relationship between stress and behavioral changes after exposing animals to 2h immobilization stress. We also evaluated the concentration of corticosterone, glucose and endogenous leptin levels in unstressed and stressed animals to explore the possible role of HPA axis in the modulation of stressed induced behavioral deficits. Rats were divided into stressed and unstressed groups. Behavioral activities were monitored in open field activity and light dark transition box after the termination of 2h immobilization period. Animals were then decapitated and plasma samples were collected for catalase, SOD, corticosterone, and glucose estimation. Results showed that exposure to acute stress produced a significant decrease in the activity of rats in the novel environment (open field) and light dark transition box. On the other hand, concomitant elevated level of peripheral markers of oxidative stress such as oxidative enzymes, corticosterone and endogenous leptin were also observed. Therefore, current study seems to suggest an important role of compounds having antioxidant properties for the treatment of stress and related disorders.

Page(s): 859-867

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 41, Issue: 5, Year: 2019

Keywords:

oxidative stress , leptin , HPA axis , acute stress

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