Abstract:
1,2,4-Triazine is one of the best known heterocyclic systems and is still very popular among scientists designing new structures with biological activity. This popularity is due to its chemical properties- more electron-deficient system than pyridine, pyrimidine, pyrazine, or pyridazine-which have been used to construct a variety of mono and fused derivatives involved in diverse structure- activity relationship studies. A number of literature reports indicate the widespread use of this heterocyclic system, which is still a valuable substrate for many studies, including the design of new molecules with targeted biological activity. For this purpose, the triazine scaffold can be flanked with other polycyclic moieties or used as a ligand for a heterobimetallic complex. It is worth emphasizing that 1,2,4-Triazine is a structural element of the various formulations used in medicine and agriculture.1 Growth of interest in the chemistry of 1,2,4- triazine has occurred due to the diverse biological activity of its derivatives which includes antibacterial, antiviral, anti-inflammatory, antiarrhythmics, antihypertensive, anticoccidiosis, antiepileptic, cytostatic, antifungal and herbicide effects. In recent decades, methods have been developed to synthesize derivatives of 1,2,4-triazine which rely on the direct introduction of the alkyl or aryl substituents or other functional groups. The substituted 1,2,4-triazines are prepared by the condensation reaction of the readily available 1,2-diketones with semicarbazide or thiosemicarbazide derivatives or by Suzuki and Stille reactions, as well as by the nucleophilic substitution of the appropriately substituted 1,2,4- triazines. The latter reaction has been widely used in our laboratory for direct synthesis of oximes of 5-acyl-1,2,4-triazines12 which are useful substrates for the construction of 5-acyl-1,2,4- triazines, chiral 1,2,4-triazine alcohols, 2- acylpyridines, 3-acyl-5,6,7,8- tetrahydroisoquinolines and pyrazolo[4,3- e][1,2,4]triazines.
Page(s):
13-13
DOI:
DOI not available
Published:
Journal: 4th International Conference of Sciences “Revamped Scientific Outlook of 21st Century, 2025” , November 12,2025, Volume: 1, Issue: 1, Year: 2025