Analgesic and anti-inflammatory activities of Desmodium triflorum DC. | [Pakistan Journal of Biological Sciences • 2005]

Author(s):

1. Kawshik Kumar Chowdhury: Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh

2. Achinto Saha: Department of Clinical Pharmacy and Pharmacology, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh

3. Sitesh Chandra Bachar: Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

4. Joydeb Kumar Kundu: Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh

Abstract:

Successive hexane, ethyl acetate and methanol extracts of Desmodium triflorum DC were subjected to evaluate analgesic and anti-inflammatory activities in animal model. In acetic acid-induced writhing test, the ethyl acetate extract at doses of 150 and 300 mg kg-1 body weight elicited 47.60 and 57.40% inhibition of writhing reflex, respectively but the methanol extract showed 51.48% inhibition at 300 mg kg-1 body weight. Significant elongation of tail flick time was evident both in ethyl acetate and methanol extracts (69.54 and 61.72% elongation, respectively) only at the higher dose. Both the hexane and methanol extracts at a dose of 300 mg kg-1 body weight showed statistically significant (p

Page(s): 581-583

DOI: DOI not available

Published: Journal: Pakistan Journal of Biological Sciences, Volume: 5, Issue: 5, Year: 2005

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