A comparative study of antioxidant vitamins and simvastatin in hypercholesterolimic rabbits | Pakistan Journal of Pharmaceutical Sciences 2011

Author(s)

Nawazish I Husain Syed University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Shamas Arshad University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Amir Ali Rizvi Syed University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Maqsood Ahmad University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Farrakh Zia Khan University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Bashir Ahmad University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Abstract

The anti-lipidemic effects of orally administered antioxidant vitamins (vitamin A, vitamin C and vitamin E) individually and in combination were studied in cholesterol-fed rabbits and compared to the group of hypercholesterolemic animals that were treated with simvastatin. All treatment groups exhibited a decrease in serum total cholesterol, low density lipoprotein-cholesterol (LDL-C) and triglycerides concentrations, whilst vitamin C, vitamin E, the combination and simvastatin showed a more profound decrease in the lipid profile than vitamin A at different time intervals. The order of increase in high density lipoprotein-cholesterol (HDL-C) levels remained in favour of simvastatin, as none of the antioxidant vitamins treated group could exhibit a profound increase in the HDL-C.

Publication Details

Page(s) 479-484

DOI DOI not available

Published Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 24, Issue: 4, Year: 2011

Keywords

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