Therapeutic evaluation of anti-angiogenic and chemotherapy with or without cox-2 inhibitor and immunomodulator drug in the management of canine mammary neoplasm. | [Pakistan Veterinary Journal • 2015]

Author(s):

1. Kodakkadan Manikkan Dileepkumar: Division of Surgery, Indian Veterinary Research Institute, Izatnagar, (UP), India

2. Swapan Kumar Maiti: Division of Surgery, Indian Veterinary Research Institute, Izatnagar, (UP), India

3. Naveen Kumar: Division of Surgery, Indian Veterinary Research Institute, Izatnagar, (UP), India

4. Malik Mohammad Shams-Uz-Zama: Division of Surgery, Indian Veterinary Research Institute, Izatnagar, (UP), India

Abstract:

The present study was conducted for exploring the activity of anti-angiogenic and chemotherapeutic treatment with or without cox-2 inhibitor and immunomodulator drug in the management of spontaneous canine mammary neoplasms. Antiangiogenic drug (Tamoxifen) (n=10), chemotherapy (5-FU) (n=10), chemotherapy (5-FU) along with cox-2 inhibitor (Etoricoxib) (n=10), chemotherapy (5-FU) along with cox-2 inhibitor (Etoricoxib) and immunomodulator drug (Levamisole) (n=10) were used in 40 female dogs having spontaneous mammary neoplasms. Anticancer drug (5-FU) and anti-angiogenic drug (Tamoxifen) induced apoptosis in canine mammary neoplasms. Immunomodulator drug (Levamisole) along with cox-2 inhibitor (Etoricoxib) and chemotherapeutic drug (5–fluorouracil) induced significantly (P

Page(s): 365-370

DOI: DOI not available

Published: Journal: Pakistan Veterinary Journal, Volume: 35, Issue: 3, Year: 2015

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