Author(s):
1. Nashwa Shoukry M. Shahin:
Biochemistry Division, Chemistry Department, Faculty of Science, Al-Azhar University (Girls Branch), Cairo, Egypt
2. Mona A. Mohamed:
Biochemistry Division, Chemistry Department, Faculty of Science, Al-Azhar University (Girls Branch), Cairo, Egypt
3. Hanaa Hussein El-Sayed:
Nutritional Chemistry and Metabolism Department, National Nutrition Institute, Cairo, Egypt
Abstract:
Diabetes mellitus is the causative disease of vascular problems that lead to structural and functional alterations as well as organ malfunction. Aim of the study to clarify the antidiabetic influences of aqueous extract of Commiphora molmol (Myrrh), including measurement of hepatic insulin as well as glucose homeostasis in alloxan-induced diabetic rats. Thirty adult female albino rats (120-140 g) were divided into 3 groups: Group I: marked as control, Group II: diabetic rats (injected with 120 mg of Alloxan/kg B.wt) and Group III: treated rats received oral doses of Commiphora molmol aqueous extract (0.5g/kg B.wt.) for 30 days. Oral administration of the plant extract considerably lowered the sugar as well as insulin levels towards the normal values of the control group. The rats were sacrificed, blood samples were kept individually for biochemical analysis, and the liver tissue of each animal was removed for gene expression of glucose transporters-4 (GLUT-4), insulin receptor (IR), insulin receptor substrate-1 (IRS-1) and histopathological examination. Result of the present experiment showed the plant ameliorated MDA and TAC levels and improvement of lipid metabolism. Myrrh could be considered as a diet supplement in the procedure of diabetes treatment through insulin signals improvement.
Page(s):
2094-2104
DOI:
DOI not available
Published:
Journal: Bioscience Research, Volume: 19, Issue: 4, Year: 2022
Keywords:
Diabetes
,
MDA
,
Diabetes
,
Diabetes
,
insulin receptor
,
Commiphora molmol
,
TAC
,
Glucose transporters
References:
References are not available for this document.
Citations
Citations are not available for this document.