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A paradigm Shift: the New Novel Oral Anticoagulation Agents.
Author(s):
1. Wajeeha Saeed: Department of Cardiology, Heart Failure and Transplant. Albert Einstein College of Medicine, New York, USA
2. James F. Burke: Department of Cardiology, Lankenau Medical Center, Wynnewood, Pennsylvania, USA; Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
3. Ghazi Mirrani: Department of Cardiology, Lehigh Valley Hospital, Allentown, Pennsylvania, USA
4. Minisha Sirinivasa: Department of Cardiology, Lankenau Medical Center, Wynnewood, Pennsylvania, USA; Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
5. Usman Nabi: Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
6. Umar Hayat: Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
7. Zubair Khan: Department of Cardiology, Cooper University Hospital, Rowan School of Medicine, Camden, New Jersey, USA
8. Muhammad Rizwan Sardar: Department of Cardiology, Cooper University Hospital, Rowan School of Medicine, Camden, New Jersey, USA; Department of Cardiology, Rhode Island Hospital, Warren Alpert School of Medicine of Brown University, Providence, Rhode Island, USA
Abstract:
Atrial fibrillation (AF) is the most common arrhythmia and represents one-third of the arrhythmia-related hospital admissions in the developed countries. Embolic strokes associated with AF are more severe and disabling. Thromboembolic stroke prevention is a major goal in treatment of AF and Warfarin has successfully served this purpose for many years. Drug-drug interaction and regular monitoring with Warfarin pose a significant challenge where health care system has limited resources; and lack of a well-structured health system, hinders regular International Normalized Ratio (INR) monitoring. Novel oral anticoagulants (NOACs) have opened up a new exciting chapter in the field of anticoagulation in non-valvular atrial fibrillation (NVAF). This review discussed the landmark trials that led to the development of NOACs and explored the potentials of these new agents with simultaneous comparison of Warfarin.
Page(s): 611-619
DOI: DOI not available
Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 26, Issue: 7, Year: 2016
Keywords:
Atrial fibrillation Stroke Coumadin New oral anticoagulation agents International Normalized Ratio INR
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