Ameliorative Effects of Monoammonium- Glycyrrhizinate on Liver Lipid Metabolism and Antioxidant Capacity in Laying Hens | [Pakistan Journal of Zoology • 2021]

Author(s):

1. Mengke Wang: Laboratory of Environment and Livestock Products, Henan University of Science and Technology,Luoyang 471023,P. R. China

2. Shucheng Huang: College of Animal Science and Veterinary Medicine, Henan Agricultural University,Zhengzhou 450002,P. R. China

3. Cai Zhang: Laboratory of Environment and Livestock Products, Henan University of Science and Technology,Luoyang 471023,P. R. China

4. Haizhou Gong: Laboratory of Environment and Livestock Products, Henan University of Science and Technology,Luoyang,P. R. China

5. Shunan Cuan: Laboratory of Environment and Livestock Products, Henan University of Science and Technology,Luoyang,P. R. China

6. Shuaishuai Wang: Laboratory of Environment and Livestock Products, Henan University of Science and Technology,Luoyang,P. R. China

7. Qi Shao: Laboratory of Environment and Livestock Products, Henan University of Science and Technology,Luoyang,P. R. China

8. Wenhao Xu: Laboratory of Environment and Livestock Products, Henan University of Science and Technology,Luoyan,P. R. China

9. Sudan Meng: Laboratory of Environment and Livestock Products, Henan University of Science and Technology,Luoyang,P. R. China

10. Pengfei Li: Laboratory of Environment and Livestock Products, Henan University of Science and Technology,Luoyang,P. R. China

11. Yuqin Wang: Laboratory of Environment and Livestock Products, Henan University of Science and Technology,Luoyang,P. R. China

12. Zijun Yang: Laboratory of Environment and Livestock Products, Henan University of Science and Technology,Luoyang,P. R. China

Abstract:

Liver injury is elicited by a complex mechanisms involving free radical-induced oxidative stress, whichcan cause considerable injury to commercial laying hens. However, the effects of monoammoniumglycyrrhizinatein improving liver lipid metabolism and antioxidant capacity of laying hens is unclear.The current study examined the ameliorative effects of monoammonium-glycyrrhizinate (MAG) onliver lipid metabolism and antioxidant capacity in laying hens. One hundred eighty 320-day-old Hy-Line brown laying hens were allocated to five equal groups and administrated with the concentrationsof 0 (control), 25, 50, 100, and 200 mg/L of MAG supplementation in the drinking water, respectively.The histological analysis results by Oil Red O and TUNEL staining showed that lipid deposition andhepatocytes apoptosis in the MAG treated groups were significantly lower than that in the controlgroup. Blood biochemical indexes also revealed that MAG supplementation significantly decreased theactivity of alanine aminotransferase (ALT) (p<0.05), the content of total protein (TP), albumin (ALB)and globulin (GLB) (p<0.05). Furthermore, supplementation of MAG increased the activity of totalsuperoxide dismutase (T-SOD) (p<0.05), slightly increased the activities of total antioxidant capacity(T-AOC) (p>0.05) and catalase (CAT) (p>0.05). And the concentrations of malondialdehyde (MDA)were reduced in MAG groups, yet the differences were not significant (p>0.05). Notably, Liver weight,liver index, and triglyceride (TG) content were diminished significantly compared with the control group(p<0.05). These results demonstrated that supplementation of MAG to drinking-water of layers canenhance the antioxidant capacity, improve lipid metabolism and has a protective on liver injury, while nodose dependence was found in this study.

Page(s): 2427-2434

DOI: 10.17582/journal.pjz/20191112021125

Published: Journal: Pakistan Journal of Zoology, Volume: 53, Issue: 6, Year: 2021

Keywords:

Antioxidant capacity , liver injury , Laying hens , Lipid metabolism , Monoammoniumglycyrrhizinate

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views