Author(s):
1. Iqra Ejaz:
Department of Oral Biology, University of Health Sciences, Lahore, Pakistan
2. Sarah Ghafoor:
Department of Oral Biology, University of Health Sciences, Lahore, Pakistan
Abstract:
Wingless-Integrated/Beta-catenin (WNT/b-catenin) signalling pathway is one of the principal intercellular signalling pathways in humans. It plays an intrinsic role in the cellular proliferation, differentiation and regeneration along with many other cellular functions. Epigenetic deoxyribonucleic acid methylations and silencing of WNT signalling pathway genes have a significant role in malignant transformation of oral lesions such as oral submucous fibrosis, oral leukoplakia, oral lichen planus and erythroplakia. The increase in WNT inhibitory proteins along with inflammatory factors cause bone loss in periapical lesions, such as chronic apical periodontitis. This review discusses the molecular genetics of potentially malignant oral lesions, sheds light on our understanding of WNT/b-catenin signalling in bone loss pertaining to periapical lesions, and alteration of this pathway for therapeutic benefits.
Page(s):
1687-1692
DOI:
DOI not available
Published:
Journal: Journal of Pakistan Medical Association, Volume: 69, Issue: 11, Year: 2019
Keywords:
Periapical lesions
,
Oral lesions
,
Malignant transformation
,
WNT signalling
References:
References are not available for this document.
Citations
Citations are not available for this document.