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The chemistry of sulphonyl coumarin derivatives.
Author(s):
1. Richard J. Cremlyn: Division of Chemical Science, Hatfield Polytechnic Hertfordshire, England, UK
2. Sally M. Clowes: Division of Chemical Science, Hatfield Polytechnic Hertfordshire, England, UK
Abstract:
When 6-chlorosulphonyl coumarin (2) was reacted with amines the derivatives (3) were formed. Condensation of 2 with N,N-dimethylhydrazine and hydrazine hydrate afforded the hydrazides (4,5); N-methylhydrazine gave a mixture of the N(1)- and N(2)-methylhydrazides (8,7). 3-(N-phenylcarboxamido) coumarin (9) reacted with chlorosulphonic acid to yield the R-sulphonyl chloride (10). Subsequent treatment with nucleophilic reagents afforded the derivatives (11,12,13). The spectral properties of the compounds are briefly discussed.
Page(s): 97-104
DOI: DOI not available
Published: Journal: Journal of Chemical Society of Pakistan, Volume: 10, Issue: 1, Year: 1988
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