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Synthesis, Characterization and Anticancer Activity of Isonicotinylhydrazide Metal Complexes.
Author(s)
Mansoor Ahmed. Department of Pharmaceutical Chemistry, University of Karachi, Karachi-75270, Pakistan.
Zi-Ning Lei Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA.
Mohsin Ali Department of Chemistry, University of Karachi, Karachi-75270, Pakistan
Syed Imran Ali Department of Applied Chemistry & Chemical Technology, University of Karachi, Karachi-75270, Pakistan.
Konatsu Kojima Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA.
Pranav Gupta Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA
Majid Mumtaz Department of Chemistry, University of Karachi, Karachi-75270, Pakistan
Dong-Hua Yang Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA.
Syed Moazzam Haider Industrial Analytical Center (ICCBS), University of Karachi, Karachi-75270, Pakistan
Zhe-Sheng Chen Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY 11439, USA.
Abstract
Summary: This study focuses characterization of iron (II), iron (III), cobalt (II), copper (II) and nickel (II) complexes of Isoniazid (INH) and studying their spectroscopic as well as physiochemical properties. FTIR studies showed that INH binds the metal from oxygen of carbonyl group and nitrogen of amino group. The proton NMR spectra of the metal complexes confirmed the conversion of ligand molecules into their respective metal complexes. However, pattern of splitting and shapes of peaks was observed but the protons resonated in the expected region. XRD patterns may be concluded that the complexes are mostly comprised of nano-sized particles behaving like amorphous materials. Scanning electron microscopy (SEM) revealed marked changes in the morphology of complexes, and their degradation at higher temperature strengthens the hypothesis of the successful formation of complexes. The MTT cytotoxicity assay was used for the screening these complexes against four human cell lines but the results did not prove significant. 
Publication Details
Page(s) 113-121
DOI DOI not available
Published Journal: Journal of Chemical Society of Pakistan, Volume: 41, Issue: 1, Year: 2019
Keywords
isoniazid Drug Metal Complexes Scanning electron microscopy XRay Diffraction and Cytotoxicity
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