Urinary excretion of trimethoprim in female volunteers. | [Pakistan Journal of Life and Social Sciences • 2003]

Author(s):

1. Atira Munir: Department of Chem, Univ. Agric, Faisalabad, Pakistan

2. Rakhshanda Nawaz: Department of Chem, Univ. Agric, Faisalabad, Pakistan

3. Faqir Hussain Khan: Department Physiol.&. Pharmac. University of Agric, Faisalabad, Pakistan

4. Rizwan Munir: Depertment of Chemistry, University of Punjab, Lahore, Pakistan

Abstract:

The urinary excretion of free trimethoprim (TMP) was studied in eight healthy adult female volunteers. Urine samples were collected at predetermined time intervals after giving a single therapeutic dose (160 mg trimethoprim + 800 mg sulfamethoxazole) orally. The concentration of trimethoprim in urine was determined by spectrophotometery. The total urinary excretion of free trimethoprim is 6.26 percent during 12 hours. It was concluded that urinary excretion of TMP was high in foreign subjects due to difference in environmental conditions. The study was conducted in month of July so the rate of urine flow was less.

Page(s): 57-58

DOI: DOI not available

Published: Journal: Pakistan Journal of Life and Social Sciences, Volume: 1, Issue: 1, Year: 2003

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