ACE GENE AND ITS ASSOCIATIONS DISORDERS WITH INFLAMMATION OR INFLAMMATORY | [International Journal of Biology and Biotechnology • 2022]

Author(s):

1. Iqra Riasat: Genetic and Molecular Genetic Research group, Department of Bioinformatics and Biosciences, Capital University of Science and Technology, Islamabad, Pakistan

2. Naveed Iqbal Soomro: Genetic and Molecular Genetic Research group, Department of Bioinformatics and Biosciences, Capital University of Science and Technology, Islamabad, Pakistan

3. Amna Noor: Genetic and Molecular Genetic Research group, Department of Bioinformatics and Biosciences, Capital University of Science and Technology, Islamabad, Pakistan

4. Javed Iqbal: Deputy District Health Office, Rawalpindi, Pakistan

5. Syeda Marriam Bakhtiar: Biosciences,Capital,Genetic and Molecular Genetic Research group, Department of Bioinformatics and University of Science and Technology,Islamabad,Pakistan

Abstract:

Angiotensin I-converting enzyme (ACE) gene as part of the renin-angiotensin system (RAS) is involved in the maintenance of body fluids, salts and majorly in regulation of blood pressure levels. ACE is a potent vasoconstrictor of the RAS and is a vasodilator of a kallikrein-kinin system that has impact on the process of inflammation. Inflammation is generally body's defence mechanism however if inflammation is slow and long lasting for prolonged periods of several months to years it is than called as chronic inflammation and is a disease condition. ACE I/D polymorphism is seen to be associated with many inflammatory diseases. This study aims to determine the frequency and association of I/D Polymorphism in the Pakistani population and its distribution among various ethnicities. The objectives were to determine the frequency of I/D in various ethnicities and to determine the association of I/D polymorphism with inflammatory diseases. The cross-sectional study was carried comprising 400 subjects. Anthropometric measurements were taken; body mass index was calculated. Diabetes was assessed by measuring blood sugar levels. Cardiovascular disease condition was assessed by measuring blood pressure and lipid profiling. Psychiatric disorder of subjects was assessed by asking questions related to standard indicators of anxiety and depression. The biochemical analyzer was used for complete reactive protein and lipid profiling. I/D polymorphism was identified through genetic screening via PCR. Statistical analysis was done to observe associations and chi-square values and odds ratios were calculated. For ACE gene I/D polymorphism in the population 67.2% was insertion while 32.75% was a deletion. The prevalence of diabetes was observed at 14% no significant association was observed with ACE gene Polymorphism. Prevalence of obesity was observed 54% no significant association was observed with ACE gene Polymorphism. The prevalence of Cardiovascular disorder was observed at 35% in our selected population and there was no significant association observed with ACE gene Polymorphism. The prevalence of the psychiatric disorders that were observed 55%, association with ACE gene polymorphism was not significant. We found that deletion increases genetic susceptibility towards obesity, cardiovascular disorders, diabetes, and psychiatric disorders. However, this is a preliminary study and the results need to be confirmed in a larger cohort.

Page(s): 413-422

DOI: DOI not available

Published: Journal: International Journal of Biology and Biotechnology, Volume: 19, Issue: 4, Year: 2022

Keywords:

Obesity , Polymorphism , Diabetes , inflammation , Diabetes , Ace gene

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