Unfractionated heparin and low molecular weight heparin in patients with acute coronary syndrome –A meta analysis. | [Journal of Cardiovascular Diseases • 2019]

Author(s):

1. Rehan Anwar: Department of Medicine, Khawaja Muhammad Safdar Medical College / Allama Iqbal Memorial Teaching Hospital,Sialkot, Pakistan

2. Hamid Khalil: Punjab Institute of Cardiology,Lahore,Pakistan

3. Atif Maqsood: Aziz Fatimah Medical and Dental College Faisalabad,Pakistan

4. Hassam Zulfiqar: Rawalpindi Medical University,Pakistan

5. Umair Asghar: Punjab Institute of Cardiology,Lahore,Pakistan

Abstract:

BACKGROUND: The choice of antiplatelet therapy and their efficacy and safety concerns are vital points to be discussed. The primary aim of this review was to evaluate the safety and efficacy of the low molecular weight heparin (LMWH) and unfractionated heparin (UFH) in patients presenting with acute coronary syndrome (ACS) patients. METHODS: This was a meta analysis / review where clinical trials were searched which compared the unfractionated heparin and heparin with lower-molecular weight in patients with ACS using PubMed search. All trails of patients with ACS population that were treated with aspirin and fibrinolytic therapy were included whereas all trails which were randomized, comparative of low molecular weight heparin with UFH and who had piloted in ACS patients were also included. RESULTS: A total of 9 trails were reviewed that constituted almost 48000 individuals. The number of individuals in STEM1 trails was almost 25000. Among the trails, 5 trials were open labeled and 4 trials were double blinded. In STEMI trails most of the patients were given fibrin-specific lyrics. Other trails included patients with high risk features and almost 80% had raised cardiac biomarkers. CONCLUSION: It is concluded from this review that the utmost suitable heparin type for ACS patients is Low molecular weight heparin (LMWH) that holds superior efficacy and lesser complications while comparing with the UFH.

Page(s): 3-7

DOI: DOI not available

Published: Journal: Journal of Cardiovascular Diseases, Volume: 15, Issue: 1, Year: 2019

Keywords:

Acute Coronary syndrome , Cardiac biomarkers , unfractionated heparin UFH

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