25-Hydroxyvitamin D is closely related with the function of the pancreatic islet ß cells. | [Pakistan Journal of Medical Sciences • 2013]

Author(s):

1. Jingjing Guo: Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China

2. Zhengda Xiao: Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China

3. Xia Xue: Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China

4. Xin Liu: Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China

5. Yong Lu: Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China

6. Xiao Yin: Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China

7. Kun Ma: Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan, P R China

Abstract:

Objectives: This study is to investigate the relationship between 25-Hydroxyvitamin D (25-OH-D) and pancreatic islet β cell function under different glucose tolerance statuses in China. Methodology: Totally, 180 patients with type 2 diabetes mellitus (DM group), 178 patients with impaired fasting glucose/impaired glucose tolerance (IFG/IGT group), and 160 normal control subjects (NGT group) were included to measure their body parameters and biochemical parameters. In oral glucose tolerance test, fasting serum 25-OH-D was assessed by the enzyme-linked immunosorbent assay (ELISA). Homeostasis model assessment for insulin resistance (Homa-IR), insulin acuity index (IAI), β-cell function index (Homa- BCF) as well as secretion index (IS) were determined. Results: The levels of 25-OH-D, IAI and Homa-BCF in the DM group and IFG/IGT group were significantly lower than that in NGT group (P

Page(s): 809-813

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 29, Issue: 3, Year: 2013

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