Two easy and early methods for the diagnosis of H. pylori i.e: Serum anti H. pylori antibodies and stool antigen. | [Journal of Liaquat University of Medical and Health Sciences • 2013]

Author(s):

1. Rasheed Ahmed Soomro: Department of Pathology, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, Sindh, Pakistan

2. Tanveer Ahmed Sheikh: Department of Pathology, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, Sindh, Pakistan

3. Amir Iqbal Memon: Department of Surgery, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, Sindh, Pakistan

4. Nazir Ahmed Pathan: Department of Pathology, Liaquat University of Medical and Health Sciences (LUMHS), Jamshoro, Sindh, Pakistan

5. Nasreen Qazi: Department of Pharmacology, Liaquat University of Medical & Health Sciences (LUMHS), Jamshoro, Sindh, Pakistan

Abstract:

Objective: Two easy methods for the diagnosis of h pylori i.e: Serum Anti H Pylori Antibodies & Stool Antigen. Materials and Methods: Hundred serum and stool samples collected from the department of surgery, and Medicine were registered at Department of Pathology and Diagnostic and Research Lab LUMHS, Jamshoro/ Hyderabad for performing H. pylori diagnosis were included in this Study. Patients of all age groups and both sexes with complain of dyspepsia, or having the clinical suspicion of H. pylori associated gastritis were included. Patients having H/O NSAIDs, or eradication therapy were excluded. A specially designed proforma was used for recording the relevant data. The Period of study was 15-10-2009 to 28-02-2011. Results: From 100 cases of, H. pylori antibodies were found in 68(68 %). 38(55.9%) were male and 30(44.1%) were females. Sensitivity of this technique was 75.55% and specificity 60%. p value 0.007. From stool samples collected from 100 patients H. pylori antigen were positive in 48 (48%) cases detected on immunochromatography technique. Stool antigen positive was in 28(58.3%) males and 20(41.7%) Female patients. The stool antigen sensitivity was 52.74% and specificity 90% P value (0.011). Conclusion: H. pylori positivity is highly significant in histological examination of endoscopic biopsies on H&E and Giemsa Stains The detection of anti H. pylori antibodies from serum by ELISA method and the H. pylori antigen from stool samples by immunochromatographies method, can be non invasive simplest, least expensive and alternatives in patients unwilling for endoscopy.

Page(s): 87-90

DOI: DOI not available

Published: Journal: Journal of Liaquat University of Medical and Health Sciences, Volume: 12, Issue: 2, Year: 2013

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