Rosuvastatin and Simvastatin potentiate antihypertensive effect of amlodipine through vasorelaxation phenomenon | Pakistan Journal of Pharmaceutical Sciences 2023

Author(s)

Niaz Ali Department of Pharmacology, College of Medicine, Shaqra University,Shaqra,Saudi Arabia

Wajid Ali Department of Pharmacology, Institute of Basic Medical Sciences, Khyber Medical University,Peshawar,Pakistan

Abid Ullah Department of Pharmacy, Shaheed Benazir Bhutto University Sheringal,Dir Upper,Pakistan

Shujaat Ahmad Department of Pharmacy, Shaheed Benazir Bhutto University Sheringal,Dir Upper,Pakistan

Haya Hussain Department of Pharmacy, Shaheed Benazir Bhutto University Sheringal,Dir Upper,Pakistan

Waqar Ali Department of Pharmacy, Abasyn University,Peshawar,Pakistan

Abstract

This study is carried out to assess the effects of rosuvastatin and simvastatin on blood vessels for possible vasorelaxant effect. The study is also translating the possible vasorelaxant effect in Wistar rats for a subsequent fall in systolic blood pressure. It is evident from the EC50, that rosuvastatin is more effective on relaxing N.E induced contractions, while simvastatin is more effective on relaxing KCL induced contractions. Simvastatin is equipotent when compared to effects of amlodipine on KCl induced contractions in denuded aortae. Simvastatin produced significant right shift in test concentration 1.1× 10-6M with its respective EC50 -1.85logCa++M as compared to its respective control EC50 3logCa++M. Rosuvastatin also produced significant right shift in the EC50. In conclusion, it is stated that rosuvastatin and simvastatin relax the aortic strips preparations through inhibition of voltage gated calcium channels and inhibition of N.E induced contractions. Rosuvastatin and simvastatin have additive effects when used in the presence of a standard vasorelaxant drug like amlodipine, which further confirms its additive effect on decreasing the systolic blood pressure of hypertensive rats (P<0.05).

Publication Details

Page(s) 953-961

DOI 10.36721/PJPS.2023.36.3.SP.953-961.1

Published Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 36, Issue: S3, Year: 2023

Keywords

Simvastatin amlodipine Statins Rosuvastatin Verapamil calcium channel blocking activity

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