The Ring Formation Mechanism in Cyclization of Berberine | [Journal of Chemical Society of Pakistan • 2021]

Author(s):

1. Guosheng Wang: Shenyang Universi ty of Chemical Technology, Liaoning Shenyang, 110142 Yuelan Wang, Xinjiang University, Xinjiang Wulumuqi, 830046

2. Siyu Han: Shenyang Universi ty of Chemical Technology, Liaoning Shenyang, 110142 Yuelan Wang, Xinjiang University, Xinjiang Wulumuqi, 830046

3. Ronghui Xu: Shenyang Universi ty of Chemical Technology, Liaoning Shenyang, 110142 Yuelan Wang, Xinjiang University, Xinjiang Wulumuqi, 830046

Abstract:

Berberine hydrochloride is a natural alkaloid with significant antitumor activities against many types of cancer cells, can be synthesized by cyclic reaction with hydrochloride condensate and glyoxal as raw materials and copper chloride as catalyst. In this study, the transition and energy change for the each reaction step was calculated by the density functional theory program Dmol3 in Materials Studio 2017. and the results testified that there are two ring formation in the cycliztion process, and according to the result we proposed the mechanism of this cyclization reaction. We also use infrared and ultraviolet spectroscopy to monitor the reaction process in real time and prove the ring formation process. The reaction mechanism was firstly proposed at the basic results of above.

Page(s): 308-313

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 43, Issue: 3, Year: 2021

Keywords:

Introduction , Reaction mechanism , Berberine , Cyclic reaction

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