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Transcriptome Signatures Focusing on Immune-Related Genes in the Livers, Spleens and Kidneys of Male and Female Takifugu rubripes
Author(s):
1. Jun Cui: College of Fisheries and Life Science, Dalian Ocean University,Dalian, China; School of Bioengineering, Dalian University of Technology, Dalian, China
2. Lei Men: College of Life Science, Dalian Minzu University, Dalian, China
3. Zhicheng Wang: College of Fisheries and Life Science, Dalian Ocean University, Dalian, China
4. Xuemei Qiu: College of Fisheries and Life Science, Dalian Ocean University, Dalian, China
5. Xiuli Wang: College of Fisheries and Life Science, Dalian Ocean University, Dalian, China
Abstract:
To obtain information regarding immune-related genes and provide a genetic basis for the immune response in fish, we performed transcriptomic comparison analysis of the livers, spleens and kidneys of male and female Takifugu rubripes. The GO terms associated with cell surface receptor signaling were the most significantly enriched, and among the KEGG pathways, cytokine-cytokine receptor interaction, an immune-related pathway, was present in all the male groups. In addition, expression level of complement C1q tumor necrosis factor-related protein 4-like (CTRP4-like) gene was upregulated in all the male samples, while the expression levels of voltage-dependent calcium channel subunit alpha-2/delta-2-like (CACNA2D2like) and protein L-Myc-1b-like genes were upregulated in all the female samples. These results demonstrate the regulatory mechanisms of immune-related genes and provide candidates for the enhancement of pathogen resistance in T. rubripes. 
Page(s): 783-793
DOI: 10.17957/IJAB/15.1501
Published: Journal: International Journal of Agriculture and Biology, Volume: 24, Issue: 4, Year: 2020
Keywords:
Kidney , liver , RNASeq , Takifugu rubripes , immunerelated genes
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