Attenuation of Nicotine Induced Behavioral Sensitization by 4- Fluoro-N-(4-Sulfamoylbenzyl) Benzene sulfonamide (F2) | [Abstract Book on International Conference on Life Sciences (ICLS-23) 11-12 May 22-23 • 2023]

Author(s):

1. Naeem Ur Rehman: Department of Pharmacy, Gomal University Dera Ismail Khan, Khyber Pakhtoonkhwa, 29220 Pakistan

2. M. Sona Khan: Head of the Pharmacy Services Department, Ayub Teaching Hospital Abbottabad, Khyber Pakhtoonkhwa, 22060, Pakistan

3. A. Tokhi: Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Khyber Pakhtoonkhwa, 22060, Pakistan

4. Mehreen Arif: Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Khyber Pakhtoonkhwa, 22060, Pakistan

5. Khalid Rauf: Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Khyber Pakhtoonkhwa, 22060, Pakistan

Abstract:

Frequent exposure to nicotine produces a persistent increase in locomotors effects of mice a phenomenon called sensitization. Due to nicotine sensitization relapse is the most common outcome. The aim of this study to study the effect of sulfonamides in nicotine induced behavioral sensitization. We investigate the effect of synthetic Sulphonamides on the acquisition and expression of nicotine induced behavioral sensitization in mice. Selected groups of mice were administered nicotine 0.5mg/kg, while one group receives saline for seven consecutive days. After 3 days of drug free period two groups received saline and nicotine respectively, while test groups receive F2 compound at a dose of 20,40,60mg/kg orally. One hour after drug administration challenged dose of nicotine was administered and locomotor activity was observed on day 1,3,5,7 and 11. In another set of experiment selected group of mice were administered concomitant F2 compounds 20, 40, 60 mg/kg once daily before nicotine 0.5mg/kg using the same protocol for the same period of time to the entire groups. After 3 days of abstinence period challenge dose of nicotine was administered and locomotion activity was observed after at, 3, 5, 7 and 11 days. Our finding showed that F2 compound in all 3 doses significantly attenuated acquisition and expression of nicotine behavioral sensitization in mice

Page(s): 62-62

DOI: DOI not available

Published: Journal: Abstract Book on International Conference on Life Sciences (ICLS-23) 11-12 May 22-23, Volume: 0, Issue: 0, Year: 2023

Keywords:

drug addiction , Sulphonamides , Pharmacotherapy , locomotor activity , nicotine sensitization

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