Abstract:
The reaction of 1-(4-anilino) morpholine/piperidine (1) with carbon disulfide, chloroace-tic acid and hydrazine hydrate in ethanol yielded 4-(N-morpholino/piperidino) - phenylthiosemicarbazide (II) which on condensation with carbonyl compounds such as benzaldehyde, isatin, N-methylisatin furnished (VI), (VII) and (VIII) respectively. Treatment of (II) with sodium nitrate and hydrochloric acid afforded 5-4-(N-morpholino)-anilino 1„2,3,4 thiatriazole (IX). (I) on condensation with ethyl chloracetate followed by reaction with hydrazine hydrate afforded (III) which when treated with isation, and N-methyl isatin, yielded (IV & V) respectively. 2-methyl-3- (4-N-morpholino/ piperidino)phenyl-4-quinazolinones (X) and 2-styryl-3- 4-N-morpholinolpiperledino Phenyl-4 quinazoli-nones (XI) were also designed using 1.
Page(s):
117-123
DOI:
DOI not available
Published:
Journal: Journal of Chemical Society of Pakistan, Volume: 8, Issue: 2, Year: 1986