Abstract:
Parkinson (PD) is one of the most common neurodegenerative diseases, which is characterized by an induce programmed cell death. It is associated with aggregation of a-synuclein and selective death of dopaminergic neurons in the substantia nigra, thereby leading to cognitive and motor impairments. The available drugs provide only symptomatic relief to PD therefore, indicating urgent need for explore new drugs against PD, especially from plant origin. The Dendrobium nobilLindl (DNL) is a good source of phytochemicals for instance alkaloids, flavonoids glycosides, benzyl derivatives, phenantherenes and phenylpropanoids. This study aimed to investigate the anti-Parkinson activity of the extractsof Dendrobium nobillin, by using Caenorhabditis elegans model instead of environmental induced toxin model of rodent. The DNL was found effective to increase life span of C. elegans and the aging process had reduced to fifty percent in PD model. The dominergic behavior of C. elegans depicted significant improvements in movement and memory/intellect properties when treated with DNL that were assessed using Basal Slowing Food searching, and Area restricted assay models. DNL effectively reduced a-synuclein aggregation that reduced dopaminergic activities. The neuroprotective action of DNL was marvelous even in 6-OHDA intoxicated model.
Page(s):
50-50
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
antioxidant
,
Parkinsons disease
,
neuroprotective
,
Herbal treatments
,
DNL