Testicular toxicity induced by deltamethrin in albino mice. | [Pakistan Journal of Zoology • 2012]

Author(s):

1. Asma Rashid: Department of Zoology, Govt Science College, Wahdat Road, Lahore, Pakistan

2. Asmatullah: Department of Zoology, University of the Punjab, Lahore, Pakistan

3. Nabiha Zara: Department of Zoology, Govt Science College, Wahdat Road, Lahore, Pakistan

4. Chaman-Ara: Department of Zoology, University of the Punjab, Lahore, Pakistan

Abstract:

The objective of this study was to investigate the toxic potential of deltamethrin on the development of testis in mice. The histopathological changes induced by deltamethrin were assessed in two groups. Different concentrations of deltamethrin 0.00, 3.00 and 5.00 µg/g BW were used repeatedly for 15 and 30 days. After dosing mice were acclimatized for some days. The testes were recovered at 45th day from treatment. Histological examinations revealed significant alterations in the testes of all dose groups. Histological abnormalities observed were hyalinization, vacuolization, exfoliated spermatocytes, dilation and tubular deformity, tubular destruction and atrophy, cellular vacuolated degeneration, apical sloughing and multilayered seminiferous epithelia with late spermatids lining the lumen of the seminiferous tubules in the testis. The observed pathological changes were dose concentration and exposure time duration dependent. It is concluded that the concentrations of deltamethrin used during the present study proved toxic in mice.

Page(s): 1349-1353

DOI: DOI not available

Published: Journal: Pakistan Journal of Zoology, Volume: 44, Issue: 5, Year: 2012

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