Acetylcholinesterase and butyrylcholinesterase inhibitory potential of some Pakistani medicinal plants. | [Journal of Basic and Applied Sciences • 2006]

Author(s):

1. Rafeeq Alam Khan: Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

2. Lshfaq Ali Bukhari: Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

3. Sarfraz Ahmad Nawaz: HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

4. Muhammad Iqbal Choudhary: HEJ Research Institute of Chemistry, International Center for Chemical Sciences University of Karachi, Pakistan

Abstract:

The crude extracts of some selected Pakistani medicinal plants, namely Acacia modesta, Buddleja crispa, Carthamus oxycantha, Conyza bonariensis and Tanacetum artemisioides were assessed for their inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). All the tested plant extracts exhibited dose dependent (0.25-1.0 mg/mI) inhibitory effects against both these enzymes with more selectivity for IBChE. A. modesta and C. bonariensis showed activity against BChE only. The plant extracts of B. crispa, C. oxycantha and T. artemisioides caused maximum inhibition of AChE at 1.0 mg/ml with % inhibition of 28, 34 and 48 respectively. In the BChE inhibitory evaluation all the tested plant extracts at 1.0 mg/ml produced marked inhibition (68-80%) of the enzyme activity. The results show the presence of selective BChE inhibitory constituents in the aforementioned plant extracts.

Page(s): 7-10

DOI: DOI not available

Published: Journal: Journal of Basic and Applied Sciences, Volume: 2, Issue: 1, Year: 2006

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