Abstract:
Antibodies to the gamma-aminobutyric acid-B receptor (Anti-GABA-B-R) mediate an uncommon subtype of autoimmune encephalitis (AE) in which IgG antibodies directed against the B1 subunit of the GABA-B-R has been described. Clinically it presents as limbic encephalitis (LE) which is characterized by seizures, psychosis, and memory loss with progression to autonomic dysfunction, altered consciousness, and death. We present a case of an elderly male who presented in the ER due to progressive agitation, confusion, and irritability. Immunological workup revealed anti-GABA-B-R and anti-Hu antibodies. After admission, his consciousness rapidly deteriorated over the next few days, and he was intubated. The patient developed septic shock and due to poor prognosis, the patient's family requested withdrawal of ventilatory support.
Keywords:
Septic shock
,
antiHu antibody
,
Autoimmune encephalitis
,
GABA B receptor
,
Paraneoplastic antibody
,
Limbic encephalitis