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Update on pharmaceutical effect of local interferon alfa-2b therapy in ocular surface disorders
Author(s):
1. Mitra Akbari: Department of Eye, Eye Research Center, Amiralmomenin Hospital, School of Medicine, Guilan University of Medical Science,Rasht,Iran
Abstract:
In this review study, efficacy and side effects of interferon alfa-2b (IFN-a2b) in treating the common ocular surface disorders is described. It was found that 1 million IU/mL of topical interferon alpha-2b administered four times daily was effective in treating various ocular surface disorders, including vernal keratoconjunctivitis, Ocular surface squamous neoplasia, conjunctival papilloma, and conjunctival melanoma. The treatment showed a significant decrease in symptoms and signs of the diseases and, in some cases, resulted in tumor regression with high tolerance and safety. Irritation was the most common reported adverse effect and complications after treatment with topical IFN-a2b are rare and not severe. IFN-a2b administration intralesionally effectively reduced the conjunctival lymphoma lesions with a dose of 1-1.5 mIU. There is limited reference to mention the effects of this interferon in epidemic keratoconjunctivitis.
Page(s): 232-236
DOI: DOI not available
Published: Journal: Rawal Medical Journal, Volume: 50, Issue: 1, Year: 2025
Keywords:
Conjunctivitis , Interferon , Pterygium , ocular surface disorder , interferon alpha2b
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