Age-related frequency of triple negative breast cancer in women. | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2014]

Author(s):

1. Muhammad Tanveer Sajid: Department of Surgery, Combined Military Hospital (CMH), Rawalpind, Pakistan

2. Muhammad Ahmed: Department of Surgery, Combined Military Hospital (CMH), Rawalpind, Pakistan

3. Muhammad Azhar: Department of Histopathology, Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan

4. Qurat-Ul-Ann Mustafa: Department of Surgery, Combined Military Hospital (CMH), Rawalpind, Pakistan

5. Irfan Shukr: Department of Surgery, Combined Military Hospital (CMH), Rawalpind, Pakistan

6. Muhammad Ahmed: Department of Surgery, Combined Military Hospital (CMH), Rawalpind, Pakistan

7. Zainab Kamal: Department of Surgery, Military Hospital, Rawalpindi, Pakistan

Abstract:

Objective: To determine frequency of triple negative breast cancer (TNBC) in Pakistani women with respect to age. study design: observational study. place and duration of study: Armed Forces Institute of Pathology (AFIP), Rawalpindi, from July 2005 to July 2010. Methodology: Pathological records of all specimens of breast cancer were reviewed and data was obtained for estrogen receptor (ER), progesterone receptor (PR) and HER-2 neu receptor proteins. Specimens having complete record of all three proteins were included for analysis. TNBC was defined as those who were ER, PR and HER-2 neu negative. Overall frequency as well as frequency with respect to age was calculated. Descriptive and categorical variables were analyzed using SPSS version 17. Results: Eight hundred and fifteen patients out of 4715 (17.28%) were found to be TNBC. Mean age of diagnosis of TNBC was found to be 46.26 ± 12.22 years of age while other breast cancers had a mean age 52.90 ± 9.78 years (p 50 years while majority of patients with other breast cancers were elderly females (p

Page(s): 400-403

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 24, Issue: 6, Year: 2014

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