Acute Renal Injury in patient with Severe Acute Pancreatitis | [Pakistan Journal of Medical and Health Sciences • 2022]

Author(s):

1. POORAN MAL: Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro,Pakistan

2. GHULAM FAREED: Isra University & Hospital Hyderabad,Pakistan

3. NAND LAL SEERANI: LLiaquat University of Medical and Health Sciences (LUMHS) Jamshoro,Pakistaniaquat University Hospital Hyderabad.Pakistan

4. AHMED HUSSAIN PATHAN: Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro,Pakistan

5. ABDUL SALAM MEMON: Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro,Pakistan

6. SHAH NAWAZ KHATTI: Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro,Pakistan

7. MUHAMMED KHALID SHAIKH: Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro,Pakistan

8. SAMAR RAZA: Liaquat University Hospital Hyderabad,Pakistan

9. SYED ZULFIQUAR ALI SHAH: Liaquat University of Medical and Health Sciences (LUMHS) Jamshoro,Pakistan

Abstract:

To determine the frequency of acute renal injury in patients with severe acute pancreatitis Methods: It is an observational research where patients coming at tertiary care hospital analyzed as severe acute pancreatitis of either gender were examined. Acute pancreatitis was determined when patients introducing to have pain in abdomen, ascend in serum amylase or potentially lipase > multiple times of ordinary reach and radiological discoveries reminiscent of acute pancreatitis. Acute kidney injury (AKI) was named when individuals with past ordinary renal capacity created decay of renal capacities with ascend in creatinine >2 mg/dl with decrease in urine output to under 0.5mg/kg/hr for 6 hours or more. Results: In our study out of fifty patients of severe acute pancreatitis 20 (40%) were males and 30 (60%) females, 15 women had history of gallstones while the history of alcohol was observed in 10 males and 02 females. The mean age ± SD for whole population is 58.85 ± 8.52. The pain abdomen was present in all patients followed by vomiting in 80%, jaundice was present in 30% cases and fever in 28%. The acute kidney injury has been detected in 32 (64%) of patients and 16 (32%) patients required renal haemodialysis (replacement therapy). The mean ± SD of hemoglobin (g/dl), WBC (x103 cells per cumm), serum potassium, urea, creatinine and bicarbonate for AKI population is 9.52±3.21, 27.85±10.95, 5.63±2.73, 268±20.85, 12.94±8.53 and 15.73±92.21. The mean ± SD of days of kidney insult and haemodialysis sessions for AKI population is 12.75±96.62 and 6.86±4.85 while the frequency (and %) of circulatory failure and deranged INR have been observed in 12 and 21 AKI patients. Conclusion: AKI is an incessant complication of acute pancreatitis and normally creates after the malfunction of different organs.

Page(s): 26-27

DOI: 10.53350/pjmhs2216526

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 16, Issue: 05, Year: 2022

Keywords:

Acute renal injury , Acute renal failure and Acute pancreatitis

References:

[1] Singh VK,Bollen TL,Wu BU,Repas K,Maurer R,Yu S,Mortele KJ,Conwell DL,Banks PA .2011 .An assessment of the severity of interstitial pancreatitis. Clin Gastroenterol Hepatol, 9(12) : 1098-103.

[2] Chatila AT,Bilal M,Guturu P .2019 .Evaluation and management of acute pancreatitis. World J Clin Cases, 7(9) : 1006-1020.

[3] Zerem E. .2014 .Treatment of severe acute pancreatitis and its complications. World J Gastroenterol, 20(38) : 13879-13892.

[4] Hirota M,Sugita H,Maeda K,Ichibara A,Ogawa M. .2004 .Concept of SIRS and severe acute pancreatitis. Nihon Rinsho, 62(11) : 2128-36.

[5] Andersson R,Andersson B,Andersson E,Axelsson J,Eckerwall G,Tingstedt B .2007 .Acute pancreatitis from cellular signalling to complicated clinical course. HPB (Oxford), 9(6) : 414-420.

[6] Vengadakrishnan K,Koushik AK K .2015 .A study of the clinical profile of acute pancreatitis and its correlation with severity indices. Int J Health Sci (Qassim), 9(4) : 410-417.

[7] Pupelis G .2000 .Renal failure in acute pancreatitis, timing of dialysis and surgery. Przegl Lek, 57(Suppl 5) : 29-31.

[8] Petejova N,Martinek A .2013 .Acute kidney injury following acute pancreatitis: A review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 157(2) : 105-13.

[9] Gaberman P,Atlas DH,Kammerling EM,Ehrlich L,Isaacs J .1951 .. Renal Anoxia Syndrome: A Review and Report of 22 Cases. Ann Int Med, 35 : 148-168.

[10] Lin HY,Lai JI,Lai YC,Lin PC,Chang SC,Tang GJ .2011 .Acute renal failure in severe pancreatitis: A population-based study. Upsala J of Med Sci, 116 : 155-159.

[11] Whitcomb DC. Acute,Pancreatitis DC. Acute .2006 .. N Engl J Med, 354(20) : 2142-2150.

[12] Wang GJ,Gao CF,Wei D,Wang C,Ding SQ .2009 .Acute pancreatitis: etiology and common pathogenesis. World J Gastroenterol, 15(12) : 1427-1430.

[13] Manohar M,Verma AK,Venkateshaiah SU,Sanders NL,Mishra A .2017 .Pathogenic mechanisms of pancreatitis. World J Gastrointest Pharmacol Ther, 8(1) : 10-25.

[14] Cruz-Santamaría DM,Taxonera C,Giner M. .2012 .Update on pathogenesis and clinical management of acute pancreatitis. World J Gastrointest Pathophysiol, 3(3) : 60-70.

[15] Fan BG,Andrén-Sandberg A .2010 .Acute pancreatitis. N Am J Med Sci, 2(5) : 211-214.

[16] Glasbrenner B,Adler G . .Pathophysiology of acute pancreatitis. Hepatogastroenterology, 40(6) : 517-21.

[17] Ljutic D,Piplovic-Vukovic T,Raos V,Andrews P .1996 .Acute renal failure as a complication of acute pancreatitis. Renal Fail, 18 : 629-33.

[18] Kong L,Santiago N,Han TQ,Zhang SD .2004 .Clinical characteristics and prognostic factors of severe acute pancreatitis. World J Gastroenterol, 10 : 3336-8.

[19] Tran DD,Oe PL,de Fijter CWH,van der Meulen J,Cuesta MA .1993 .Acute renal failure in patients with acute pancreatitis: prevalence, risk factors and outcome. Nephrol Dial Trans, 8 : 1079-1084.

[20] Kumar R. Acute .2015 .Kidney Injury in Severe Acute Pancreatitis: An Experience from a Tertiary Care Center Saudi J Kidney Dis Transpl. , 26(1) : 56-60.

[21] Lin H .2011 .Acute renal failure in severe pancreatitis: A population-based study. Upsala Journal of Medical Sciences, 116 : 155-159.

[22] Naqvi R. Acute .2018 .Kidney Injury in association with Acute Pancreatitis. Pak J Med Sci, 34(3) : 606.

[23] Heung M. Outpatient . .Dialysis for Acute Kidney Injury: Progress and Pitfalls. Am J Kidney Dis, 74(4) : 523-528.

[24] Hertzberg D,Ryden L,Pickering JW,Sartipy U,Holzmann MJ U .2017 .Acute kidney injury-an overview of diagnostic methods and clinical management. Clin Kidney J, 10(3) : 323-331.

Citations

Downloads

Views