A Comparative Change in Left Ventricular Mass Index on Echocardiography in Hypertensive Diabetic and Non-Diabetic Patients Taking Candesartan | [Pakistan Journal of Medical and Health Sciences • 2023]

Author(s):

1. TAYYABA NASIR: Govt. koi khawaja Saeed teaching hospital/KEMU Lahore, Pakistan.

2. SAKHAWAT ABBAS: Govt. koi khawaja Saeed teaching hospital/KEMU Lahore, Pakistan.

3. UMAR KHALIL: Mayo Hospital/KEMU Lahore, Pakistan.

4. TEHREEM NASIR: University of Medical and Dental College Faisalabad, Pakistan.

5. MUHAMMAD KALEEM: Govt. koi khawaja Saeed teaching hospital/KEMU Lahore, Pakistan.

6. MUHAMMAD SHAHZAD ASLAM: DHQ Teaching Hospital, Sargodha Pakistan

7. UMAIR KHALID: Govt. koi khawaja Saeed teaching hospital/KEMU Lahore, Pakistan.

Abstract:

Background: To assess the evolution of the left ventricular mass index on echocardiography in candesartan-treated hypertension individuals with and without diabetes. Study Design: This is a cross-sectional comparative study. Place and Duration: The present study was conducted from June 2022 to February 2023. Methodology: A total of 120 male and female patients of 35-55 years of age, fulfilling inclusion and exclusion criteria were selected for this study and divided into two groups i.e. Group-A and Group B. In Group-A 60 diabetic type-2 hypertensive patients were considered while in Group B 60 non-diabetic hypertensive patients were included. Patients of both groups were treated with candesartan. Raw data was operated through SPSS version 2022 with the Mean standard deviation regression (Mean ± SD). Results: Significant changes (P=0.05) in both groups were seen, the hypertensive diabetic patients showed Mean standard Deviation value (35.65 ± 5.93) whereas hypertensive non-diabetic patients showed Mean standard Deviation value (21.95 ± .48) respectively. Practical Implications: In the current study there was an echocardiographic comparison of left ventricular mass index changes in both diabetic and non-diabetic hypertensive patients was concluded with candesartan cilexetil. The findings of this clinical trial are so beneficial for hypertensive patients to manage their self. Practical implication This study compared the effect of candesartan on left ventricular mass index in hypertensive diabetic and non-diabetic patients. The results showed that candesartan was more effective in reducing left ventricular mass index in hypertensive diabetic patients. This study provides useful information for the management of hypertension in diabetic patients of the community. Conclusion: Candesartan reduced left ventricular mass index more in hypertensive diabetic as compared to non-diabetic hypertensive patients. Both diabetic and non-diabetic hypertensive patients had a reduction in blood pressure with candesartan. With the considerable BP drop, candesartan is a viable treatment for hypertensive diabetic patients.

Page(s): 569-572

DOI: 10.53350/pjmhs2023173569

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 17, Issue: 3, Year: 2023

Keywords:

Hypertensive , Diabetics , Candesartan and Left ventricular index , posterior wall thickness

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