Amelioration of food intake by Mentha piperita in restraint rats | [Pakistan Journal of Biochemistry and Molecular Biology • 2011]

Author(s):

1. Tahira Parveen: Neurochemistry & Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, PAKISTAN

2. Naila Amin: Neurochemistry & Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, PAKISTAN

3. Darakhshan J. Haleem: Neurochemistry & Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, PAKISTAN

4. Saida Haider: Neurochemistry & Biochemical Neuropharmacology Research Laboratory, Department of Biochemistry, University of Karachi, Karachi, PAKISTAN

Abstract:

Mentha piperita, commonly known as peppermint have been used in herbal medicines and food industries for the treatment of various kinds of illnesses. The present study conducted to investigate the effect of Mentha piperita on restraint induced decreases in food intake. 2h restraint stress decreased food intake rats. These stress induced deficits in food intake is not observed in the rats treated with Mentha piperita. Role of 5-HT in eating behavior is well established. It is observed in the present study that exposure to 2h restraint stress increased brain 5-HT and 5-HIAA levels. Prior administration of Mentha piperita leave extract for 5 week decreased 5-HT and 5-HIAA levels. Results are discussed in context of increased 5-HT turns over following repeated administration of Mentha piperita in restrained rats.

Page(s): 110-112

DOI: DOI not available

Published: Journal: Pakistan Journal of Biochemistry and Molecular Biology , Volume: 44, Issue: 3, Year: 2011

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