A comparative study of antioxidant vitamins and simvastatin in hypercholesterolimic rabbits | [Pakistan Journal of Pharmaceutical Sciences • 2011]

Author(s):

1. Nawazish I Husain Syed: University College of Pharmacy, University of the Punjab, Lahore, Pakistan

2. Shamas Arshad: University College of Pharmacy, University of the Punjab, Lahore, Pakistan

3. Amir Ali Rizvi Syed: University College of Pharmacy, University of the Punjab, Lahore, Pakistan

4. Maqsood Ahmad: University College of Pharmacy, University of the Punjab, Lahore, Pakistan

5. Farrakh Zia Khan: University College of Pharmacy, University of the Punjab, Lahore, Pakistan

6. Bashir Ahmad: University College of Pharmacy, University of the Punjab, Lahore, Pakistan

Abstract:

The anti-lipidemic effects of orally administered antioxidant vitamins (vitamin A, vitamin C and vitamin E) individually and in combination were studied in cholesterol-fed rabbits and compared to the group of hypercholesterolemic animals that were treated with simvastatin. All treatment groups exhibited a decrease in serum total cholesterol, low density lipoprotein-cholesterol (LDL-C) and triglycerides concentrations, whilst vitamin C, vitamin E, the combination and simvastatin showed a more profound decrease in the lipid profile than vitamin A at different time intervals. The order of increase in high density lipoprotein-cholesterol (HDL-C) levels remained in favour of simvastatin, as none of the antioxidant vitamins treated group could exhibit a profound increase in the HDL-C.

Page(s): 479-484

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 24, Issue: 4, Year: 2011

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