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A comparative study of antioxidant vitamins and simvastatin in hypercholesterolimic rabbits
Author(s):
1. Nawazish I Husain Syed: University College of Pharmacy, University of the Punjab, Lahore, Pakistan
2. Shamas Arshad: University College of Pharmacy, University of the Punjab, Lahore, Pakistan
3. Amir Ali Rizvi Syed: University College of Pharmacy, University of the Punjab, Lahore, Pakistan
4. Maqsood Ahmad: University College of Pharmacy, University of the Punjab, Lahore, Pakistan
5. Farrakh Zia Khan: University College of Pharmacy, University of the Punjab, Lahore, Pakistan
6. Bashir Ahmad: University College of Pharmacy, University of the Punjab, Lahore, Pakistan
Abstract:
The anti-lipidemic effects of orally administered antioxidant vitamins (vitamin A, vitamin C and vitamin E) individually and in combination were studied in cholesterol-fed rabbits and compared to the group of hypercholesterolemic animals that were treated with simvastatin. All treatment groups exhibited a decrease in serum total cholesterol, low density lipoprotein-cholesterol (LDL-C) and triglycerides concentrations, whilst vitamin C, vitamin E, the combination and simvastatin showed a more profound decrease in the lipid profile than vitamin A at different time intervals. The order of increase in high density lipoprotein-cholesterol (HDL-C) levels remained in favour of simvastatin, as none of the antioxidant vitamins treated group could exhibit a profound increase in the HDL-C.
Page(s): 479-484
DOI: DOI not available
Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 24, Issue: 4, Year: 2011
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