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The polymorphism of Insulin-like growth factor-I (IGF-I) is related to osteoporosis and bone mineral density in postmenopausal population.
Author(s):
1. Li Yun-Kai: The Fifth Surgical Department, The Fourth People’s Hospital, Jinan, China
2. Wang Hui: Department of Stomatology, Jinan Traditional Chinese Medicine Hospital, Jinan, 250012, China
3. Zhu Xin-Wei: The Fifth Surgical Department, The Fourth People’s Hospital, Jinan, China
4. Guo Liang: Department of Radiotherapy, The Fourth People’s Hospital, Jinan, 250013, China
5. Zuo Jin-Liang: The Fifth Surgical Department, The Fourth People’s Hospital, Jinan, China
Abstract:
Objective: It has been shown that Insulin-like growth factor-1 (IGF-1) may be related with bone mineral density (BMD) or osteoporosis. But there are few evidences on the role of genetic variation of IGF-1 on the BMD or osteoporosis. We observed the relationship between polymorphisms of IGF-1(rs35767, rs2288377 and rs5742612) with osteoporosis and BMD in the postmenopausal female population in our study. Methods: A total of 216 postmenopausal women with a primary diagnosis of osteoporosis and 220 normal healthy women were included in the study. Genomic DNA of IGF-1 rs35767, rs2288377 and rs5742612 was extracted from the whole blood using QIAamp blood DNA mini kits (QIAGEN, Hilden, Germany) according to the methods recommended by the manufacturer. Results: We found that T allele of rs35767 had higher increased risk of osteoporosis (OR=1.34, 95%CI=1.0- 1.81). Those carrying T allele of rs35767 had a significant lower BMD at L1–L4 vertebrae, femoral neck, total hip and trochanter when compared with those carrying C allele (P Conclusion: Our study suggests that polymorphism in IGF-I rs35767 was significantly associated with BMD and osteoporosis in postmenopausal female population, and polymorphism of rs35767 could be a marker for lower BMD and risk of osteoporosis.
Page(s): 131-135
DOI: DOI not available
Published: Journal: Pakistan Journal of Medical Sciences, Volume: 30, Issue: 1, Year: 2014
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