A treatise on Occurrence, Regulation and Management of Aflatoxin M1 in Milk. | [Pakistan Journal of Food Sciences • 2016]

Author(s):

1. Muhammad Shamoon: State Key Laboratory of Food Science and Technology, The synergistic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, Peoples Republic of China

2. Muhammad Wasim Sajid: Department of Biosciences, COMSATS Institute of Information Technology, Sahiwal, Pakistan

3. Muhammad Atif Randhawa: National Institute of Food Science & Technology, University of Agriculture, Faisalabad 38040, Pakistan

4. Waseem Safdar: State Key Laboratory of Food Science and Technology, The synergistic Innovation Center of Food Safety and Nutrition, Jiangnan University, Wuxi 214122, Peoples Republic of China

5. Junaid Haider: Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Food Science and Technology Jiangnan University, Wuxi 214122, Peoples Republic of China

6. Muhammad Sohaib: Department of Food Science, Nutrition and Home Economics, Government College University, Faisalabad, Pakistan

7. Mukama Omar: Key Laboratory of Carbohydrate Chemistry and Biotechnology, School of Biotechnology, Jiangnan University, Wuxi 214122, Peoples Republic of China

Abstract:

Milk is essential for human health but it is also considered as a source of aflatoxin M1 contamination if lactating animal(s) is fed on the fungus contaminated feed. Milk contamination with AFM1 is more critical as it constitutes an important part of human diet, particularly for the young ones. Aflatoxin M1 belongs to naturally occurring group of mycotoxins and synthesized by toxicogenic filament fungi of specific genera. The causative fungi favor to grow in a wide range of suitable environmental factors and climatic conditions of humidity and temperature. Biosynthesis of AFM1 is a complex multi enzyme involving process which is governed by clusters of genes. AFM1 contamination poses an incredible burden to health care system around the globe being hepatotoxic, carcinogenic and immunosuppressive in its nature and negatively affects both animals and human that outcome in the form of ailments and economic costs. To minimize the risk of exposure numerous regulatory measures have been established worldwide as an official monitoring approach through standardized analytical methods. Although full scale mitigation of AFM1 contamination in milk is difficult to achieve yet there are several strategies that could be implemented as promising lines of future research. However, still no sole strategy has proven a complete solution to this problem.

Page(s): 38-45

DOI: DOI not available

Published: Journal: Pakistan Journal of Food Sciences, Volume: 26, Issue: 1, Year: 2016

Keywords:

Keywords are not available for this article.

References:

[1] Wiesman and E.H.,Marth, 1982.Aflatoxin: toxicity to dairy cattle and occurrence in milk and milk products- a review,J. Food Prot 45 752 -777

[2] Ardic , M.,Y.Karakaya,M.Atasever,H.Durmaz, 2008.Determination of aflatoxin B1 levels in deep-red ground pepper (isot) using immunoaffinity column combined with ELISA,Food Chem -

[3] ., 46 1596 -1599

[4] Hussain, 2012.Effect of seasonal variations and lactation times on aflatoxin M1 contamination in milk of different species from Punjab, Pakistan,Food Control 25 34 -38

[5] Ayar , A.,D.Sert,A.H.Çon, 2007.A study on the occurrence of aflatoxin in raw milk due to feeds,J. Food Safety 27 199 -207

[6] Bostan, 2006.Aflatoxin M1 levels of some cheese varieties in Turkey,Med -

[7] Bennett , J.W and K.E.,Papa,P.A.Williams, 1988.(eds.) Genetics of plant Pathogenic Fungi, 264 -280

[8] Cleveland, 1992.Oxidation-reduction 8, -

[9] Bhatnagar , E.B.,Lillehoj and D.K., .Handbook of applied mycology: mycotoxins in ecological systems,Marcel Dekker 255 -286

[10] Blount , W.P., 1961.Turkey "X" disease,J. -

[11] Br, ., 9 52 -54

[12] Galvano, 2006.Survey of the occurrence of aflatoxin M1 in ovine milk by HPLC and confirmation by MS,Mol. Nutr -

[13] Küplülü, 2005.Aflatoxin M1 contamination in pasteurised milk,Veterinarski Arhiv. -

[14] Creppy , E.E., 2002.Update of survey, regulation and toxic effects of mycotoxins in Europe,Toxicol. Letters 127 19 -28

[15] Gant , P.C.,Turner and K.H.,Dingley, 2004., -

[16] .The formation of AFB1-macromolecular adducts in rat and human and dietary levels of exposure,Food Chem. Toxicol 42 559 -569

[17] Postel , W.T.P.,Dijksma , A.,Dujardin and C.M.,Placinta, 1998.Pesticide use and mycotoxin production in Fusarium and Aspergillus pathogens,Eur. J. Plant Pathol. -

[18] .Levels of aflatoxin M1 in milk, cheese consumed in Kuwait and occurrence of total aflatoxin in local and imported animal feed, -

[19] FoodControl, ., 20 686 -690

[20] Deveci , O,E.Sezgin, 2005.Aflatoxin M1 levels of skim milk powders produced in Turkey,J. Food Drug Anal 13 139 -142

[21] Diaz , G.J and E.,Espitia, 2006.Occurrence of aflatoxin M1 in retail milk samples from Bogota, Colombia, -

[22] Lino, 2013.Aflatoxin M1 in marketed milk in Portugal: Assessment of human and animal exposure,Food Control 30 411 -417

[23] EC (EuropeanCommission)., 2010., -

[24] .Commission regulation (EC) No. 165/2010 of 26 February 2010 amending regulation (EC) No 1881/2006 setting the maximum levels for certain contaminants in foodstuffs as regards aflatoxins,Official J. Euro. Union 8 -11

[25] Fallah , A.A., 2010.Assessment of aflatoxin M1 contamination in pasteurized and UHT milk marketed in central part of Iran,Food Chem. Toxicol 48 988 -991

[26] Saei-Dehkordi, 2011.Seasonal variation of aflatoxin M1 contamination in industrial and traditional Iranian dairy products,Food Control 22 1653 -1656

[27] .Agriculture Organization of the United Nations,PPLPI Working Paper No.3 -

[28] Neyestani and S.H.,Mirhendi, 2007., -

[29] .Occurrence of aflatoxin M1 in raw milk during the summer and winter seasons in Hamedan, Iran,J. Food Safety 27 188 -198

[30] Giovati , L.,W.Magliani,T.Ciociola,C.Santinoli,S.Conti,L.Polonelli, 2015., -

[31] .AFM1 in Milk: Physical, Biological, and Prophylactic Methods to Mitigate Contamination,Toxins 7 4330 -4349

[32] Gong , Y.,A.Hounsa,S.Egal,P.C.Turner,A.E.Sutcliffe,A.J.Hall, 2004.Post weaning exposure to aflatoxin results in impaired child growth: a longitudinal study in Benin, West Africa,Environ. Health Perspect 112 1334 -1338

[33] Moltó and J.,Mañes, 2008.Simple liquid chromatography assay for analyzing ochratoxin A in bovine milk,Food Chem -

[34] Gürbay , A,S.Aydin,G.Girgin,A.B.Engin,G.Şahin, 2006.Assessment of aflatoxin M1 levels in milk in Ankara, Turkey,Food Control 17 1 -4

[35] Heshmati , A,J.M.Milani, 2010., -

[36] .Contamination of UHT milk by aflatoxin M1 in Iran,Food Control 21 19 -22

[37] Höhler , D., 2000.A brief survey on important mycotoxins and possible detoxification methods,Feed Tech. -

[38] Munawar and M.,Kashif, .Aflatoxin M1 contamination in milk from five dairy species in Pakistan,Food Con 21 122 -124

[39] Hussein , H.S.,J.M.Brasel, 2001., -

[40] ., 167 101 -34

[41] IARC, 2002.Monograph on the evaluation of carcinogenic risk to human,IARC (International Agency for Research on Cancer) 82 -

[42] Iqbal , S.A.,M.R.Asi, 2013.Assessment of aflatoxin M1 in milk and milk products from Punjab, Pakistan,Food Con 30 235 -239

[43] Hussain, 2009.Analysis of milk production system in peri-urban areas of Lahore (Pakistan) a case study,Pak. Econ. Soci. -

[44] ., 47 229 -242

[45] 2011.Review of mycotoxin reduction in food and feed: From prevention in the field to detoxification by adsorption or transformation,Food Addit. -

[46] Contam. Part A, ., 28 1590 -1609

[47] Kamkar , A., 2005.A study on the occurrence of aflatoxin M1 in raw milk produced in Sarab city of Iran,Food Control 16 593 -599

[48] Marnissi , B.E.,R.Belkhou,D.P.Morgavi,L.Bennani,H.Boudra, 2012., -

[49] .Occurrence of aflatoxin M1 in raw milk collected from traditional dairies in Morocco,Food Chem. Toxicol 50 2819 -2821

[50] Moghima , H and H.,Shirzad, 2011.Survey of Aflatoxin in pasteurized and local raw milk in Shahrekord city and suburbs (Abstracts),Clinic Biochem 1 -366

[51] S.Gallina,M.Rastelli,G.L., 2011.,doi:10 08 -

[52] Ferro and L.,Decastelli, 2007.Regional monitoring plan regarding the presence of aflatoxin M1 in pasteurized and UHT milk in Italy,Food Control 18 623 -629

[53] Sonal, 2005.Aflatoxin M1 in raw milks collected from plain and mountain villages in Bursa, Turkey, -

[54] Hajimahmoodi and A.,Nikzad, 2007., -

[55] .Presence of aflatoxin M1 in milk and infant milk products in Tehran, Iran, -

[56] Lee, 2009.Detection of aflatoxin M1 in milk products from China by ELISA using monoclonal antibodies,Food Control. -

[57] Wennberg, 1989.Carry-over of aflatoxin from dairy cattle feed to milk,World Association of Veterinary Food Hygienists Symposium 97 -102

[58] Glamočić, 2009.Two year study of incidence of aflatoxin M1 in milk in the region of Serbia, -

[59] Rahimi , E.,M.Bonyadian,M.Rafei,H.R.Kazemeini, 2010.Occurrence of aflatoxin M1 in raw milk of five dairy 55., -

[60] Razavilar , V., 2003.Pathogenic microorganisms in foods and epidemiology of food borne intoxications, 197 -201

[61] .A survey of aflatoxin M1 in milk and sweets of Punjab, Pakistan, -

[62] .Aflatoxin occurrence in food stuff supplied to dairy cattle and aflatoxin M1 in raw milk in the north of Parana state,Food Chem. Toxicol 43 981 -984

[63] Shundo , L and M.,Sabino, 2006.Aflatoxin M1 in milk by immunoaffinity column cleanup with TLC/HPLC determination, -

[64] Braz. J.Microbiol, ., 37 164 -167

[65] Viswanath, 2012.Occurrence of aflatoxin M1 in some samples of UHT, raw & pasteurized milk from Indian states of Karnataka and Tamilnadu, -

[66] ., 50 4158 -4162

[67] .Occurrence of aflatoxins in mahua (Madhuca indica Gmel.) seeds: synergistic effect of plant extracts on inhibition of Aspergillus flavus growth and aflatoxin production,Food Chem. Toxicol 47 774 -777

[68] Steyn , P.S., 1995.general view, chemistry and structure,Toxicol Lett. -

[69] Mahdavi, 2008.Aflatoxin M1 contamination in winter and summer milk in 14 states in Iran,Food Control 19 1033 -1036

[70] Siddique, 2007.Introduction,In Proceedings of the workshop on monitoring of chemical adulterants and hygienic status of market milk. Lahore 7 -39

[71] Townsend , C.A., 1997.Progress towards a biosynthetic rationale of the aflatoxins pathway,Pure Appl. Chem 58 227 -238

[72] Unusan , N., 2006.Occurrence of aflatoxin M1 in UHT milk in Turkey, -

[73] ., 1897 -1900

[74] Van Egmond , H.P., 1989.Current situation on regulations for mycotoxins. Overview of tolerances and status of standard methods of sampling and analysis,Food Addit. Contam. -

[75] Veldman , A.,J.A.C.Meijs,G.J.Borggreve,J.J. Heeres van der Tol., 1992.Carry over of aflatoxin from cows' food to milk, -

[76] AnimProd, ., 55 163 -168

[77] Yabe , K.,Y.Ando,T.Hamasaki, 1991a., -

[78] .Desaturase activity in the branching step between aflatoxins B1 and G1 and aflatoxins B2 and G2,Agric. Biol. Chem 55 1907 -1911

[79] Yu , J.,D.Bhatnagar,K.C.Ehrlich, 2002., -

[80] ., 19 191 -200

[81] Zheng , N.,P.Sun,J.Q.Wang,Y.P.Zhen,R.W.Han,X.M.Xu, 2013.Occurrence of aflatoxin M1 in UHT milk and pasteurized milk in China market,Food Con 29 198 -201

[82] .Presence of aflatoxin M1 in pasteurized milk from Morocco,Int. J. Food Microbiol 114 25 -29

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