A Review on the Applications of Potassium Permanganate in Veterinary Medicine: Toxicity, Efficacy and Future Considerations | [Pakistan Veterinary Journal • 2024]

Author(s):

1. Talha Umar: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University,Wuhan,People's Republic of China

2. Liu Wenjing: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University,Wuhan,People's Republic of China

3. Huili Feng: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University,Wuhan,People's Republic of China

4. Wen Feng: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University,Wuhan,People's Republic of China

5. Ma Bin: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University,Wuhan,People's Republic of China

6. Zaima Umar: Department of Anatomy, the University of Faisalabad,Faisalabad, 38000 Punjab,Pakistan

7. Muhammad Naeem: Department of Veterinary Medical Sciences, University of Parma,Parma I-43100,Italy

8. Abdul Sami Umar: Bolan Medical College,Quetta, 87300 Balochistan,Pakistan

9. Sana Asif: Department of Theriogenology, Faculty of Veterinary Science, University of Agriculture,Faisalabad, 38000 Punjab,Pakistan

10. Muhammad Usman: Department of Basic Sciences (Histology), University of Veterinary and Animal Sciences,Lahore,Pakistan

11. Deng Ganzhen: Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Huazhong Agricultural University,Wuhan,People's Republic of China

Abstract:

Potassium permanganate (KMnO4) solution, a potent oxidizing agent, has been extensively employed in veterinary medicine for uterine washing, wound cleansing, and many other therapeutic purposes. However, its related toxicity and adverse effects often remain unnoticed due to its extensive use as an antiseptic and disinfectant. This review aims to explore the potential risks and harmful effects of using potassium permanganate in veterinary medicine. Through an indepth review of the scientific literature and authoritative analysis, this article discusses the significance of various antiseptics, the mode of action of potassium permanganate, its pharmacokinetics, dosage, toxicity, allergenicity and historical use in the human and veterinary practices. As a vital constituent of numerous commercially important chemical entities, including medicines, potassium permanganate is used for wound cleansing and uterine flushing because it can effectively disrupt cell wall and damage DNA of pathogenic organisms, effectively mitigating bacterial and fungal infections. However, it can also adversely affect living cells, leading to inflammation, oxidative stress, and ulcerative injury. Excessive and prolonged exposure of body tissue to potassium permanganate can cause damage to vital organs such as the liver and kidneys, induce digestive system malfunctions and provoke reproductive disorders. Furthermore, it can contaminate milk and meat, and potentially instigate a reduction in milk production of the animal. The present review primarily aims to enhance veterinarians' understanding regarding the therapeutic applications and potential hazards of KMnO4, as well as to highlight the importance of its judicious use to minimize its negative repercussions on animal and human health.

Page(s): 214-221

DOI: 10.29261/pakvetj/2024.172

Published: Journal: Pakistan Veterinary Journal, Volume: 44, Issue: 2, Year: 2024

Keywords:

Dosage , Toxicity , Potassium permanganate , Veterinary medicine , Human medicine

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