The Analgesic effect of Pre-operatively Administered Combination of Dexamethasone and Tramadol on Post-operative Pain in Patients Undergoing Open Appendectomy- Randomized Clinical Trial. | [Isra Medical Journal • 2018]

Author(s):

1. Muhammad Nauman Zafar: Holy Family Hospital, Rawalpindi, Pakistan

2. Ubair Ullah Shaheen: Benazir Bhutto Hospital (BBH), Rawalpindi, Pakistan

3. Rafay Ali Khan: Benazir Bhutto Hospital (BBH), Rawalpindi, Pakistan

4. Ammar Zaman Khan: Medicine Unit-1, Holy Family Hospital, Rawalpindi, Pakistan

Abstract:

OBJECTIVE: To compare the analgesic eefct of pre-operatively administered combination of dexamethasone and tramadol ver sus tramadol only on post-operative pain scores of patients undergoing open appendectomy. STUDY DESIGN: A Randomized, double-blinded, parallel group study. PLACE AND DURATION: Study was carried out in Accident and Emergency Department of Benazir Bhuot Hospital, Rawalpindi from 1st February 2017 to 27th March 2017. METHODOLOGY: Patients undergoing open appendectomy were enrolled using the inclusion criteria and interventional protocol was randomized across two parallel groups; 1st group received pre-operative intravenous combination of dexamethasone and tramadol and the 2nd group received tramadol only. The pharmacological variables of anaesthesia were kept at a constant level for all the participants of the study. Pain was assessed at 0-4 hours post-operatively using the Numeric Rating Scale (NRS). RESULTS: There were 32 patients in 1 st group (combined dexamethasone tramadol) and 30 patients in 2 nd group (tramadol only). Mean post-operative pain score(as per NRS) at 0-4 hours was 3.06 in group 1 while it was 4.53 in group 2 (p value=0.002) Among the 1st group, a remarkable 65.6% had only mild pain(NRS 1-3) and 34.3% had moderate pain(NRS 4-6). Among the 2nd group, 30% had mild pain, 53.3% had moderate pain, while 16.6% of the patients had severe post-operative pain (NRS 7-10). Regarding rescue analgesia, only 34.3% of combined dexamethasone tramadol group had to be administered additional post-operative analgesia. CONCLUSION: Pre-operative administration of a combination of intravenous dexamethasone and tramadol results in statistically significant lesser pain scores and decreased requirement of rescue analgesia at 0-4 hours post-operatively in patients undergoing open appendectomy for acute appendicitis.

Page(s): 36-39

DOI: DOI not available

Published: Journal: Isra Medical Journal, Volume: 10, Issue: 1, Year: 2018

Keywords:

Keywords are not available for this article.

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