Adenoids and chronic secretory otitis media. | [Pakistan Journal of Otolaryngology,Head and Neck Surgery • 1991]

Author(s):

1. A. M. Talaat: Otolaryngology Department, Alexandria Facul. Medical, Alexandria, Egypt

2. M. Abdou: Otolaryngology Department, Alexandria Facul. Medical, Alexandria, Egypt

3. S. Flwany: Otolaryngology Department, Alexandria Facul. Medical, Alexandria, Egypt

4. K. Gomaa: Pharmacology Department, Alexandria Faculty of Medicine, Alexandria, Egypt

5. Y. Bahgat: Pharmacology Department, Alexandria Faculty of Medicine, Alexandria, Egypt

Abstract:

Study was conducted on 40 children with adenoids, 20 atopic and 20 non-atopic. They were divided into 4 equal groups. Group I: nonatopic without secretary otitis media (SOM), group II: non-atopic with SOM, group III: atopic with SOM and group IV: atopic with SOM and receiving levamisole for 3 months before adenoidectomy. Full history taking, thorough general and ENT examination, including audiological assessment, and blood tests were done for every patient. The removed adenoids were subjected to: 1. Direct immunofluorescent technique using fluorescene conjugated with antihuman IgA and IgE to detect B cells carrying IgA and IgE in adenoid tissue sections. 2. Estimation of histamine content by fluorometric assay of histamine in tissue. The levels of histamine, IgE and IgA were high in children with SOM as compared with children having no SOM. The role of the inflammatory mediator in adenoids was evaluated and the stimulus for its release was explained and discussed in atopic and non-atopic children. Children receiving levamisole for 3 months showed a drop in histamine content and insignificant diminution of IgE in adenoid tissue. This supports the fact that the potentiating effect of levamisole is particularly on cell mediated immunity with minimal or no effect on humoral immunity. We suggest that the benefits of adenoidectomy in children with SOM, besides producing a more physiological nasopharyngeal flora, removes a potential source of inflammatory mediators in the vicinity of Eustachian tube which have an important role in the pathogenesis of secretory otitis media.

Page(s): 134-137

DOI: DOI not available

Published: Journal: Pakistan Journal of Otolaryngology,Head and Neck Surgery, Volume: 7, Issue: 4, Year: 1991

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