Alpha-methyldopa hepatotoxicity in pregnancy. | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2009]

Author(s):

1. Tauseef Ali: Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK United States of America

2. Nandakumar Srinivasan: University of Oklahoma, Oklahoma City United States of America

3. Le Vu: University of Oklahoma, Oklahoma City United States of America

4. Rizvi Syed: University of Oklahoma, Oklahoma City United States of America

Abstract:

A 12-week pregnant, 33-year-old African American female, presented with jaundice and change in urine colour. Liver function tests revealed raised transamines and normal alkaline phosphatase. She was started on methyldopa 6 weeks prior to presentation. After initial negative investigations including viral and autoimmune hepatitis, she was given prednisone for methyldopa induced hepatitis. Two weeks later, repeat enzymes revealed normal values. Important clinical and management points related to methyldopa induced hepatotoxicity are discussed.

Page(s): 125-126

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 19, Issue: 2, Year: 2009

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