Formulation Development and in-vitro characterization of microspheres for the controlled delivery of Candesartan | [Abstract Book on International Conference on Life Sciences (ICLS-23) 11-12 May 22-23 • 2023]

Author(s):

1. Hafiz M. Jahanzaib: Department of Pharmaceutics,Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan

2. Akhtar Rasul: Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan

3. Ghulam Abbas: Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan

4. Shahid Shah: Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan

Abstract:

Hypertension is one of the serious global health issues that affect millions of people and leads to cardiovascular damage if remain untreated. In this research work, a therapy having sustained and controlled effect for the treatment of hypertension was developed. Controlled release microspheres of Candesartan were formulated for the purpose of increasing the time of retention of drug in the lower gastrointestinal tract and ultimately extend drug release. Eudragit RS100 & RL100 were used as release controlling agents. The method adopted to prepare microspheres was solvent extraction. Formulated microspheres were tested for assessing flow properties, percentage yield, drug release, surface morphology, FTIR, polymer compatibility, size analysis and entrapment efficiency. On the basis of results, formulation 1 with 1:1 drug polymer ratio was selected as optimum formulation. Entrapment efficiency of formulation increased when concentration of polymer increased. Release kinetics on cumulative released at a were applied. It was examined from the findings that all the formulations showed release in 7.4 pH buffer up to 12 hrs. It was also found that release of drug from formulation was prolonged which indicates sustained effect of the dosage form.

Page(s): 91-91

DOI: DOI not available

Published: Journal: Abstract Book on International Conference on Life Sciences (ICLS-23) 11-12 May 22-23, Volume: 0, Issue: 0, Year: 2023

Keywords:

Hypertension , cardiovascular damage

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