Anaesthetic Management of Nesidioblastosis in Two Infants. | [Journal of Ayub Medical College • 2017]

Author(s):

1. Muhammad Saad Yousuf: Department of Anaesthesiology, Aga Khan University Hospital Karachi-Pakistan

2. Mohsin Nazir Butt: Department of Anaesthesiology, Aga Khan University Hospital Karachi-Pakistan

3. Fauzia Anis Khan: Department of Anaesthesiology, Aga Khan University Hospital Karachi-Pakistan

Abstract:

Nesidioblastosis is the most common cause of non-transient, recurrent and persistent hypoglycaemia in neonates and infants. It is a disorder of diffuse proliferation of beta cells of the pancreas leading to hyperinsulinemia and hypoglycaemia. The main aim is to prevent the severe episodes of hypoglycaemia which can cause damage to the brain and/or mental retardation. In this case report we present two cases of nesidioblastosis and their perioperative anaesthetic course for near-total pancreatectomy. First case was a 7 months old female who had repeated episodes of convulsions since birth. Second case was a 4-month-old female child who again presented with seizures. The challenges faced in the perioperative period were the management of perioperative blood glucose levels and haemodynamic stability.

Page(s): 689-691

DOI: DOI not available

Published: Journal: Journal of Ayub Medical College, Volume: 29, Issue: 4, Year: 2017

Keywords:

Keywords are not available for this article.

References:

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[9] ,2017,,Received: 16 February,,,

[10] ThomasPM,CoteGJ,WohllkN,HaddadB,MathewP,RablW,,1995,Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy,Science,268,426,9

[11] KaczirekK,NiederleB. Nesidioblastosis:,,2004,an old term and a new understanding,World J Surg,28,1227,30

[12] GlaserB,ThorntonP,OtonkoskiT,JunienC,,2000,Genetics of neonatal hyperinsulinism,Arch Dis Child Fetal Neonatal Ed,82,F79,86

[13] Aynsley-GreenA,HussainK,HallJ,SaudubrayJM,NihoulFeketeC,De Lonlay-DebeneyP,,2000,Practical management of hyperinsulinism in infancy,Arch Dis Child Fetal Neonatal Ed,82,F98,107

[14] JacksonSH,JacksonSH,,1990,Genetic and metabolic diseases; Inborn errors of metabolism,Katz's anesthesia and uncommon diseases,34,6,

[15] GoswamiJ,SomkuwarP,NaikY.,,2012,Insulinoma and anaesthetic implications,Indian J Anaesth,56,117,22

[16] MarlesSL,CasiroOG,,1998,Persistent neonatal hypoglycemia: Diagnosis and management,Paediatr Child Health,3,16,9

[17] TanakaT,NabatameH,TanifujiY.,,2005,Insulin secretion and glucose utilization are impaired under general anesthesia with sevoflurane as well as isoflurane in a concentrationindependent manner,J Anesth,19,277,81

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