Volatile composition and antibacterial activity of fruits of Withania coagulans dunal | [Pakistan Journal of Scientific and Industrial Research (Series A: Physical Sciences) • 2023]

Author(s):

1. Iqra Nazir: School of Chemistry, University of the Punjab,Lahore,Pakistan

2. Azeem Intisar: School of Chemistry, University of the Punjab,Lahore,Pakistan

3. Muhammad Imran Din: School of Chemistry, University of the Punjab,Lahore,Pakistan

4. Jan Sher Khan: Department of Botany, University of the Punjab,Lahore,Pakistan

5. Ejaz Ahmed: School of Chemistry, University of the Punjab,Lahore,Pakistan

6. Aqsa Aamir: School of Chemistry, University of the Punjab,Lahore,Pakistan

7. Mujahid Manzoor: Faculty of Agricultural Sciences, University of the Punjab,Lahore,Pakistan

8. Muhammad Irfan: Department of Biomedical Physics, Doctoral School of Exact Sciences, Adam Mickiewicz University Poznan,,Poland

Abstract:

Withania coagulans Dunal is a significant medicinal plant as its fruit is used to treat numerous ailments. In this study, volatile oil of fruit of Withania coagulans was extracted by microwave associated hydro-distillation and analyzed by gas chromatography mass spectrometry that resulted in the successful identification of 40 constituents where the most dominating ones were: caprylic acid (28.58%), caproic acid (16.88%), capric acid (12.21%), lauric acid (5.77%), palmitic acid (3.49%), eugenol (3.96%) and varamol (2.95%). The fruit was found to be a major source of fatty acids (71.91%). Moreover, the antibacterial activity of the oil against various drug-resistant microbes demonstrated its potential against Pseudomonas aeruginosa (21 mm), Enterococcus faecalis (11 mm) and Methicillin resistant Staphylococcus aureus (10 mm) at a dose level of 0.48 mg. Most of these constituents are well known bioactive agents. These results demonstrate the potential of this oil as a natural source of obtaining various fatty acids and a possible remedy against various microbial diseases.

Page(s): 227-233

DOI: DOI not available

Published: Journal: Pakistan Journal of Scientific and Industrial Research (Series A: Physical Sciences), Volume: 66, Issue: 3, Year: 2023

Keywords:

volatile oil , fatty acids , Withania coagulans , dodi paneer , drugresistant bacteria

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