Very Late Relapse of Ewing Sarcoma in a Developing Country | [Pakistan Paediatric Journal • 2022]

Author(s):

1. Mahwish Faizan: Department of Paediatric Hematology/Oncology, The Children’s Hospital. University of Child Health Sciences, Lahore, Pakistan

2. Shamvil Ashraf: Department of Paediatric Hematology/Oncology, The Children’s Hospital. University of Child Health Sciences, Lahore, Pakistan

3. Mehmood Shaukat: Department of Paediatric Hematology/Oncology, The Children’s Hospital. University of Child Health Sciences, Lahore, Pakistan

4. Ahmed Farooq: Department of Paediatric Hematology/Oncology, The Children’s Hospital. University of Child Health Sciences, Lahore, Pakistan

5. Najam Ud Din: Department of Paediatric Hematology/Oncology, The Children’s Hospital. University of Child Health Sciences, Lahore, Pakistan

Abstract:

Ewing sarcoma (ES)is a rare cancer effecting children and young adults. Prognosis varies from 30 -70%. Relapse can occur within 2 years of initial diagnosis, although very late relapses have been reported. Our index patient was successfully managed for chest wall Primitive Neuroectodermal tumour (PNET) in infancy by good multidisciplinary care and later presented after seven years with very late relapse of Ewing sarcoma (ES). This is the longest duration to relapse reported in any developing country. Management was challenging. His first relapse was successfully treated with irinotecan and temozolomide based chemotherapy with complete surgical resection and chest radiotherapy. He remained well for 18 months before being presented with a second relapse that was also successfully managed. There is dire need to share experiences in managing such patients and start doing clinical trials for optimal management of such patients in developing countries to build local expertise.

Page(s): 340-343

DOI: DOI not available

Published: Journal: Pakistan Paediatric Journal, Volume: 46, Issue: 3, Year: 2022

Keywords:

Children , Relapse , Treatment , Ewing sarcoma , irinotecan , Temozolomide , Topotecan

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