A comparative analysis of frequency of in-hospital arrhythmias in patients with successful versus failed thrombolysis following acute myocardial infarction | [Pakistan Heart Journal • 2011]

Author(s):

1. Sher Bahadar Khan: Department of Cardiology Lady Reading Hospital & Khyber Medical University, Peshawar ,Pakistan

2. Rafiullah: Department of CardiologySaidu Teaching Hospital, Swat ,Pakistan

3. Abdul Hadi: Department of Cardiology Lady Reading Hospital & Khyber Medical University, Peshawar ,Pakistan

4. Syed Tahir Shah: Department of Cardiology Lady Reading Hospital & Khyber Medical University, Peshawar ,Pakistan

5. Samiullah Khan: Department of Cardiology Lady Reading Hospital & Khyber Medical University, Peshawar ,Pakistan

6. Ikramullah: Department of Cardiology Lady Reading Hospital & Khyber Medical University, Peshawar ,Pakistan

7. Muhammad Abdur Rauf: Department of Cardiology Lady Reading Hospital & Khyber Medical University, Peshawar ,Pakistan

8. Hafiz ur Rehman: Department of CardiologySaidu Teaching Hospital, Swat ,Pakistan

9. Adnan Mahmood Gul: Department of Cardiology Lady Reading Hospital & Khyber Medical University, Peshawar ,Pakistan

10. Mohammad Hafizullah: Department of Cardiology Lady Reading Hospital & Khyber Medical University, Peshawar ,Pakistan

Abstract:

Objective: To compare frequency of in-hospital arrhythmias in patients with successful and failed thrombolysis using streptokinase in patients presenting with acute myocardial infarction (AMI). Methodology: This was a comparative study conducted at department of Cardiology, Lady Reading Hospital,Peshawar from October 2006 to October 2007 .Two hundred patients with first AMI were divided into two groups: group A (successful thrombolysis) and group B (failed thrombolysis) using ECG criteria. Results: A total of 200 patients were studied. Group A included 136 (68%) patients while group B included 64 (32%) patients. Among these 24 (12.0 %) patients developed arrhythmias. Of these 8 patients were in group A and 16 patients were in group B (5.9% vs. 25.0%, p=0.003).Ventricular tachycardia was the most common arrhythmia. It was documented in 9 (4.5%) patients, with 2 patients in group A and 7 patients in group B (1.5% vs. 10.9%, p=0.003). The other arrhythmias which included atrial fibrillation, ventricular fibrillation and supraventricular tachycardia were statistically insignificant between the two groups (p=0.174). In hospital mortality was more common in patients with failed thrombolysis [6 (9.4%) vs. 3 (2.2%) (p=0.023)]. Conclusion: Failed thrombolysis is associated with complex arrhythmias and high in- hospital mortality.

Page(s): 32-36

DOI: DOI not available

Published: Journal: Pakistan Heart Journal, Volume: 44, Issue: 3--4, Year: 2011

Keywords:

Myocardial Infarction , Arrhythmias , thrombolysis

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