ADHFE1 and C-MYC Association and Over-Expression in Different Stages of Human Breast Cancer Tissues | [Pakistan Journal of Medical and Health Sciences • 2022]

Author(s):

1. SARAH SADIQ: CMH Kharian Medical College,NUMS-,Pakistan

2. UMARA ASIM: HITEC Medical College,Taxilla-,Pakistan

3. NASEEM ARSHAD: AMC,Rawalpindi-,Pakistan

4. AMBREEN JAVED: HITEC Medical College,Taxilla-,Pakistan

5. RABIA SADIQ: CMH Kharian-,Pakistan

6. RABIA HAMID: CMH Quetta-,Pakistan

7. AMBREEN SADIQ: Combined Military Hospital,Rawalpindi-,Pakistan

Abstract:

Chief enantiomer in breast tumors is D-2HG. Mitochondrial Alcohol Dehydrogenase (ADHFE I ) produces D-2HG. lt is the CA breast oncogene which leads to decreased patient survival. c-MYC can upregulate ADHFE I by changes in iron metabolism whereas co expression of c-MYC and ADHFE I greatly augment ort hotopic growth of tumor in MCF7 cells. Aims: To determine theexpression levels and localization ofc-Myc and ADHFE I in different stages of breast cancer tissue. Study Design: Cross-sectional comparative study. Methodology: Present study was conducted to enhance knowledge of c-Myc function in breast cancer by examination of relation between nuclear c-Myc and iron containing ADHFE I enzyme protein expression, using immunohistcichemistry. All this information was recorded on performa. Statistical analysis: Data was analyzed using SPSS version 25. Analysis of variance (ANOVA) test, was employed to observe mean difference between groups. Results: Nuclear c-Myc and cytoplasmic ADHFE I levels were significantly higher than controls and were positively correlated with each other in advancing stages of breast cancer. Conclusion: It was concluded that the association between the expression levels of c-Myc oncogene and ADHFE-1 enzyme existed in all advancing stages of CA Breast and the expression of both increased as the breast cancer advanced.

Page(s): 2-4

DOI: 10.53350/pjmhs22163762

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 16, Issue: 3, Year: 2022

Keywords:

Breast Cancer , cMyc , ADHFEI and Immunohistochemistry

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