The efficacy of local infiltration of triamcinolone acetonide with lignocaine compared with lignocaine alone in the treatment of Postherpetic Neuralgia | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2005]

Author(s):

1. Mohammad Amjad: Department of Dermatology, Combined Military Hospital, Peshawar. Pakistan.

2. Asher Ahmed Mashhood: Department of Dermatology, Combined Military Hospital, Peshawar. Pakistan.

Abstract:

Objective: To assess the efficacy of local infiltration of corticosteroid with lignocaine compared to lignocaine alone in the treatment of postherpetic neuralgia. Design: A randomized clinical trial. Place and Duration of Study: The Skin Department, Military Hospital, Rawalpindi from September 2002 to March 2003. Patients and Methods: Sixty patients were selected for the study. They were randomly assigned to two groups. Group-I received injection triamcinolone acetonide with lignocaine and group-ll was given injection lignocaine alone. Three injections were given to each patient at fortnightly interval and pain relief was assessed by visual analogue scale at 6 and 12 weeks following the first injection. Results: Follow-up at 6 weeks showed complete pain relief in 63.3% (n=19) patients of group-l in comparison to 16.6% (n=5) of group-ll. Chi-square value was 13.3 (p<0.001). At 12 weeks follow-up group-l showed further improvement with complete pain relief in 83.3% (n=25) whereas group-ll showed diminishing response with cure rates falling to 6.6% (n=2). Chi-square value was 35.6 (p<0.001). Conclusion: Locally infiltrated injection triamcinolone acetonide with lignocaine was significantly more effective than injection lignocaine alone in the treatment of postherpetic neuralgia both at 6 and 12 weeks follow-up.

Page(s): 683-685

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 15, Issue: 11, Year: 2005

Keywords:

Herpes zoster Postherpetic Intralesional steroids Intralesional lignocaine

References:

[1] .1999 .repeateadpplicatioonfeutectimc ixtureoflocaalnesthetics (EMLA) creamon evokedpain in postherpetniecuralgiPaa. , 81 : 203-9.

[2] McGrarMyL SeversoJn .1999 .. VaricellzaostevrirusJ.Am AcadDermatol, 41 : 1-14.

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