Abstract:
In the current era, nanotechnology plays a significant role in drug delivery systems, enabling targeted and controlled release of medications. Green synthesis refers to the production of the nanoparticles that minimizes the hazardous chemicals and energy. In the current study, the ethanolic extract and fractions of Cinnamomum verum bark were prepared and analyzed for their phytochemical composition, antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, and antimicrobial activity. The crude ethanolic extract and its four fractions were used to synthesize silver nanoparticles (Ag-NPs). The qualitative phytochemical analysis revealed the presence of phenolics, flavonoids, and alkaloids in the crude ethanolic extract. Among the fractions, the dichloromethane (F3) fraction exhibited the highest content of total phenolics, alkaloids, and antioxidant activity. Gentamicin, a synthetic antibiotic, was used as a positive control for antibacterial activity, while dimethyl sulfoxide used as a negative control. The crude ethanolic extract, its fractions and Ag-NPs synthesized from these extracts were evaluated for their antibacterial potential against nine bacterial strains (TP8, A9G, ES3, DS4, E1, 3a, HS4, KH3 & LS5). The AgNPs synthesized from the extracts exhibited the highest antibacterial activity compared to the crude ethanolic extract and its fractions that these silver nanoparticles can be further processed and effective application at antibacterial agents that could be helpful in providing organic solutions for treating diseases.
Page(s):
141-141
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Food and Applied Sciences (ICFAS-23) 3-5 August 23, Volume: 0, Issue: 0, Year: 2023
Keywords:
DPPH
,
Green synthesis
,
AgNPs
,
Cinnamomum
,
antibacterial potential